Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 17633..18210 Replicon plasmid pAHTJS2
Accession NZ_CP018873
Organism Acinetobacter haemolyticus strain TJS01

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AHTJS_RS17305 Protein ID WP_004897309.1
Coordinates 17633..17881 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AHTJS_RS17310 Protein ID WP_004897307.1
Coordinates 17878..18210 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AHTJS_RS17280 13287..14456 - 1170 WP_075316569.1 MobA/MobL family protein -
AHTJS_RS17285 14761..15534 + 774 WP_005146105.1 hypothetical protein -
AHTJS_RS17290 15649..16974 - 1326 WP_081377716.1 ISNCY family transposase -
AHTJS_RS17300 17196..17477 - 282 WP_004897311.1 hypothetical protein -
AHTJS_RS17305 17633..17881 + 249 WP_004897309.1 type II toxin-antitoxin system HicA family toxin Toxin
AHTJS_RS17310 17878..18210 + 333 WP_004897307.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AHTJS_RS17315 18274..18492 - 219 Protein_18 IS4 family transposase -
AHTJS_RS17320 18521..20104 - 1584 WP_044099894.1 IS66-like element ISAba25 family transposase -
AHTJS_RS17325 20179..20514 - 336 WP_000618091.1 IS66 family insertion sequence element accessory protein TnpB -
AHTJS_RS17330 20511..20894 - 384 WP_001055589.1 IS66 family insertion sequence hypothetical protein -
AHTJS_RS17335 20980..21394 - 415 Protein_22 DUF4372 domain-containing protein -
AHTJS_RS17340 21573..22595 - 1023 WP_171261767.1 spore coat U domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - csuD / csuA/B 1..39508 39508
- inside IScluster/Tn - - 15649..20894 5245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(54-101)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9501.14 Da        Isoelectric Point: 10.3185

>T70734 WP_004897309.1 NZ_CP018873:17633-17881 [Acinetobacter haemolyticus]
MGKTEKLLEKLGNSKNTFPYKDLVVLLSQLGYEKFEMAGSRVRFFNEKTEHMILLHRPHPENEIKGGALKAVKQALKQER
FL

Download         Length: 249 bp

>T70734 NZ_CP018873:17633-17881 [Acinetobacter haemolyticus]
ATGGGTAAAACGGAAAAGTTATTGGAAAAACTTGGAAATTCAAAAAATACATTTCCATATAAAGATTTAGTCGTTTTACT
AAGCCAACTCGGTTATGAAAAGTTTGAAATGGCAGGCTCTCGTGTTCGTTTTTTTAATGAAAAAACTGAACATATGATTT
TACTGCATAGACCACACCCTGAGAATGAAATCAAAGGCGGTGCATTGAAAGCTGTAAAACAGGCACTTAAGCAGGAGAGA
TTTTTATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12408.18 Da        Isoelectric Point: 4.8838

>AT70734 WP_004897307.1 NZ_CP018873:17878-18210 [Acinetobacter haemolyticus]
MSYLKYKGYLGTIEPDLETGELFGKVAFIRDLITYEAETLKALEQAFQESVDGYLESCIELNKKPDQPFKGTFNVRISPD
LHRKAVLASSNSLNNFVSDAIQEKLMRLGV

Download         Length: 333 bp

>AT70734 NZ_CP018873:17878-18210 [Acinetobacter haemolyticus]
ATGAGCTATCTAAAATATAAAGGTTATCTTGGAACAATTGAGCCTGATTTAGAAACAGGTGAGTTGTTTGGAAAAGTTGC
TTTTATACGTGATTTAATCACTTATGAAGCCGAAACATTAAAAGCATTAGAACAAGCTTTTCAAGAATCTGTAGATGGCT
ATTTAGAATCTTGTATCGAACTAAATAAAAAACCAGATCAGCCTTTTAAAGGTACGTTTAATGTACGGATTAGCCCTGAT
CTACACCGTAAAGCTGTTTTAGCATCAAGTAATTCCTTGAATAACTTTGTAAGCGATGCAATTCAAGAAAAGCTAATGCG
TCTAGGTGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References