Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 138922..139544 Replicon chromosome
Accession NZ_CP018871
Organism Acinetobacter haemolyticus strain TJS01

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6KIZ1
Locus tag AHTJS_RS00670 Protein ID WP_075314388.1
Coordinates 138922..139317 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6KJ14
Locus tag AHTJS_RS00675 Protein ID WP_075314389.1
Coordinates 139314..139544 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AHTJS_RS00640 134363..135274 - 912 WP_075314382.1 alpha/beta hydrolase -
AHTJS_RS00645 135464..135901 + 438 WP_075314383.1 DUF2147 domain-containing protein -
AHTJS_RS00650 135965..136315 - 351 WP_075314384.1 arsenate reductase -
AHTJS_RS00655 136757..137581 - 825 WP_075314385.1 exodeoxyribonuclease III -
AHTJS_RS00660 137623..138273 + 651 WP_075314386.1 orotate phosphoribosyltransferase -
AHTJS_RS00665 138334..138786 - 453 WP_075314387.1 ABZJ_00895 family protein -
AHTJS_RS00670 138922..139317 - 396 WP_075314388.1 type II toxin-antitoxin system VapC family toxin Toxin
AHTJS_RS00675 139314..139544 - 231 WP_075314389.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AHTJS_RS00680 139672..140391 - 720 WP_075314391.1 SDR family NAD(P)-dependent oxidoreductase -
AHTJS_RS00685 140761..141213 + 453 WP_075314393.1 GNAT family N-acetyltransferase -
AHTJS_RS00695 141364..142689 + 1326 WP_081377716.1 ISNCY family transposase -
AHTJS_RS00700 142641..142925 - 285 WP_075314395.1 DUF3565 domain-containing protein -
AHTJS_RS00705 142926..143378 - 453 WP_075314397.1 MarR family transcriptional regulator -
AHTJS_RS00710 143558..144040 + 483 WP_075314399.1 glutathione peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 141352..142689 1337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-37)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14881.11 Da        Isoelectric Point: 6.7543

>T70731 WP_075314388.1 NZ_CP018871:c139317-138922 [Acinetobacter haemolyticus]
MIYLLDTNICIYVINHKPQHVFDRFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLDILAYDEHAIWHYA
KLRHDLQSAGKSIGNLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWV

Download         Length: 396 bp

>T70731 NZ_CP018871:c139317-138922 [Acinetobacter haemolyticus]
ATGATTTACCTCTTAGACACAAATATTTGTATCTATGTGATTAATCACAAACCTCAGCACGTCTTTGACCGATTTAAACA
GTATCAACTTGGTCAGCTTGCAATTTCGAGTATCACTGCATCTGAACTTGCTTTTGGTGTAGAAAAGTCTGGATCTGAAC
GCAATAAGCAGGCACTAAACAAATTTTTATCACCTTTAGACATCTTAGCTTATGATGAGCATGCTATTTGGCATTACGCT
AAATTACGCCATGATCTTCAATCGGCAGGTAAATCTATTGGTAACTTAGATATGTTGATAGCTGCCCATGCTTTAGCGTT
GGATGTTGTCTTAGTCACGAACAATACTAAAGAATTTGAACGTATTGATGGTCTAAAGTTAGAAAATTGGGTCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8761.01 Da        Isoelectric Point: 4.8141

>AT70731 WP_075314389.1 NZ_CP018871:c139544-139314 [Acinetobacter haemolyticus]
MEIAKVFKTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAVNEFEVGFQLERADQGEQEREEFR

Download         Length: 231 bp

>AT70731 NZ_CP018871:c139544-139314 [Acinetobacter haemolyticus]
ATGGAAATTGCGAAAGTATTTAAAACAGGCCGAAGTCAGGCAGTTCGCTTGCCTAAAGCCTTCCGTTTTAATGGTACTGA
GGTCGCCATCAAAAGCTTTGGTCGTGGCGTGTTACTCATGCCCATCGACAATCCTTGGGATGTAATGTTAGAAGCTGTCA
ACGAATTTGAAGTTGGGTTCCAGTTAGAGCGAGCAGATCAAGGGGAACAAGAGCGTGAGGAATTTAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6KIZ1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6KJ14

References