70730

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4094398..4095032 Replicon chromosome
Accession NZ_CP018870
Organism Streptomyces sp. TN58

Toxin (Protein)


Gene name vapC Uniprot ID A0A0F0HI30
Locus tag BSL84_RS18580 Protein ID WP_030031567.1
Coordinates 4094398..4094820 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0F0HJF3
Locus tag BSL84_RS18585 Protein ID WP_030031568.1
Coordinates 4094817..4095032 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSL84_RS18560 4089569..4090042 - 474 WP_045320685.1 cupin domain-containing protein -
BSL84_RS18565 4090109..4090714 - 606 WP_030031575.1 Fe-S cluster assembly protein HesB -
BSL84_RS18570 4090818..4091630 + 813 WP_045320686.1 VOC family protein -
BSL84_RS18575 4091696..4094119 - 2424 WP_075970772.1 helicase-associated domain-containing protein -
BSL84_RS18580 4094398..4094820 - 423 WP_030031567.1 PIN domain nuclease Toxin
BSL84_RS18585 4094817..4095032 - 216 WP_030031568.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BSL84_RS18600 4095591..4097819 + 2229 WP_075970773.1 DNA polymerase III subunit gamma and tau -
BSL84_RS18605 4097880..4099133 + 1254 WP_030032782.1 phosphoribosylamine--glycine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-125)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-49)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15362.24 Da        Isoelectric Point: 4.7194

>T70730 WP_030031567.1 NZ_CP018870:c4094820-4094398 [Streptomyces sp. TN58]
VNAALYLIDTSALARFMRGDAEQYGWDQAAAAGLIATCPITELEFFYSARSAADRAHGIEDIRLLFGWVPVDDRAYDRAW
QVQEALTKQGRHRSAGAVDLVVAATAELQGLTLLHCDHDFEGIAALTGQPLQWYGPEGRK

Download         Length: 423 bp

>T70730 NZ_CP018870:c4094820-4094398 [Streptomyces sp. TN58]
GTGAACGCCGCGCTCTACCTGATCGACACCAGCGCCCTCGCCCGGTTCATGCGGGGCGACGCGGAGCAGTACGGCTGGGA
CCAGGCAGCGGCCGCCGGCCTGATCGCCACGTGCCCGATCACGGAGCTGGAGTTCTTCTACAGCGCCCGATCGGCCGCCG
ACCGGGCACACGGCATCGAGGACATACGGCTGCTCTTCGGCTGGGTCCCCGTCGACGACCGCGCTTACGACCGGGCCTGG
CAGGTCCAGGAGGCCCTCACCAAGCAGGGCAGGCACCGCAGCGCAGGCGCAGTCGATCTCGTCGTCGCAGCGACCGCCGA
GCTGCAGGGGCTTACCCTCCTGCACTGCGACCACGACTTCGAAGGCATCGCCGCACTAACCGGCCAGCCCCTCCAGTGGT
ACGGCCCGGAGGGGCGTAAGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8065.16 Da        Isoelectric Point: 8.6590

>AT70730 WP_030031568.1 NZ_CP018870:c4095032-4094817 [Streptomyces sp. TN58]
MSRTVIDLDDELLADVAKALGTSTKKETVNTALREVLENRRRALALTRLRAAADEGAFDLTLFEDKRNYRR

Download         Length: 216 bp

>AT70730 NZ_CP018870:c4095032-4094817 [Streptomyces sp. TN58]
ATGAGCCGGACAGTCATAGACCTCGATGACGAGCTGCTGGCAGACGTAGCCAAAGCCCTGGGCACCAGTACCAAGAAGGA
GACGGTCAACACAGCCTTGCGCGAGGTACTGGAGAACAGGCGGCGGGCGCTGGCCCTGACCCGCCTGCGCGCCGCGGCCG
ACGAAGGCGCGTTCGATCTGACGCTCTTCGAGGACAAGCGGAACTACCGACGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F0HI30

Antitoxin

Source ID Structure
AlphaFold DB A0A0F0HJF3

References