70729

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 2758445..2759010 Replicon chromosome
Accession NZ_CP018870
Organism Streptomyces sp. TN58

Toxin (Protein)


Gene name doc Uniprot ID A0A0F0H3N8
Locus tag BSL84_RS12580 Protein ID WP_030031079.1
Coordinates 2758445..2758813 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0F0GXR5
Locus tag BSL84_RS12585 Protein ID WP_030031080.1
Coordinates 2758813..2759010 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSL84_RS12565 2754493..2755290 - 798 WP_030030505.1 hypothetical protein -
BSL84_RS12570 2755446..2756087 - 642 WP_030662724.1 helix-turn-helix domain-containing protein -
BSL84_RS12575 2756512..2758296 - 1785 WP_030031078.1 DEAD/DEAH box helicase -
BSL84_RS12580 2758445..2758813 - 369 WP_030031079.1 Fic family protein Toxin
BSL84_RS12585 2758813..2759010 - 198 WP_030031080.1 Arc family DNA-binding protein Antitoxin
BSL84_RS12590 2759043..2760503 - 1461 WP_075970361.1 MFS transporter -
BSL84_RS12595 2760602..2761495 - 894 WP_030036058.1 IS982 family transposase -
BSL84_RS12600 2761678..2762226 - 549 WP_075970362.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(12-119)

Antitoxin

Arc-like DNA binding domain

(5-35)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13660.53 Da        Isoelectric Point: 4.5363

>T70729 WP_030031079.1 NZ_CP018870:c2758813-2758445 [Streptomyces sp. TN58]
MHYLTLPELLNLAERLGADEVRDYGLLDSALARPQASVFGQDAYPDIWQKAAALMESLARNHGLVDGNKRIAWYAAWVFL
HMNGHPLDPEFDVDEAEQFVLDVCQGALDVPKIAAQLPRFAR

Download         Length: 369 bp

>T70729 NZ_CP018870:c2758813-2758445 [Streptomyces sp. TN58]
ATGCACTACCTCACGCTTCCCGAGCTACTCAACCTCGCGGAGCGTCTCGGAGCGGACGAAGTGCGCGACTACGGTCTCCT
CGACTCGGCACTGGCGCGCCCGCAGGCGAGCGTGTTCGGCCAGGACGCCTACCCGGACATCTGGCAGAAGGCGGCGGCTC
TGATGGAATCGCTGGCCCGCAACCACGGGCTGGTAGACGGGAACAAGCGCATTGCCTGGTACGCGGCCTGGGTCTTCCTC
CACATGAACGGGCATCCGCTCGACCCCGAGTTCGACGTGGACGAAGCCGAGCAGTTCGTGCTGGACGTGTGCCAGGGGGC
TCTCGACGTACCCAAGATCGCTGCGCAGCTGCCGAGGTTCGCGCGCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7307.17 Da        Isoelectric Point: 5.6050

>AT70729 WP_030031080.1 NZ_CP018870:c2759010-2758813 [Streptomyces sp. TN58]
MAGLNVRFTEEELDALRERAEAEGRSMQSFAHDAVIKAVNEHSRLFNEAAEHVLKASAELNRRLA

Download         Length: 198 bp

>AT70729 NZ_CP018870:c2759010-2758813 [Streptomyces sp. TN58]
ATGGCTGGTCTCAACGTCAGATTCACCGAAGAAGAGCTGGACGCCCTGCGCGAGCGCGCCGAGGCGGAGGGCCGGAGCAT
GCAGTCCTTCGCGCACGACGCGGTCATCAAGGCCGTAAACGAACACTCCCGACTGTTCAACGAGGCGGCGGAGCATGTGC
TGAAGGCGAGCGCAGAGCTGAACCGGAGGCTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F0H3N8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F0GXR5

References