Detailed information of TA system TA070727

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 2112308..2112804
• Replicon: chromosome
• Accession: NZ_CP018863
• Organism: Arthrobacter crystallopoietes strain DSM 20117

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: AC20117_RS09995
• Protein ID: WP_074699855.1
• Coordinates: 2112550..2112804 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1H1BM97
• Locus tag: AC20117_RS09990
• Protein ID: WP_074699856.1
• Coordinates: 2112308..2112553 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AC20117_RS09975	2108823..2110211	-	1389	WP_083339628.1	MHS family MFS transporter	-
AC20117_RS09980	2110229..2111254	-	1026	WP_074699858.1	MBL fold metallo-hydrolase	-
AC20117_RS09985	2111355..2112275	+	921	WP_074699857.1	LysR family transcriptional regulator	-
AC20117_RS09990	2112308..2112553	+	246	WP_074699856.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AC20117_RS09995	2112550..2112804	+	255	WP_074699855.1	Txe/YoeB family addiction module toxin	Toxin
AC20117_RS10000	2112854..2113162	+	309	WP_074699854.1	hypothetical protein	-
AC20117_RS10005	2113203..2114099	-	897	WP_074699853.1	alpha/beta hydrolase	-
AC20117_RS10010	2114145..2115002	-	858	WP_074699852.1	hypothetical protein	-
AC20117_RS10015	2115037..2115660	-	624	WP_139186752.1	VTT domain-containing protein	-
AC20117_RS10020	2115707..2116228	+	522	WP_074699850.1	O-acetyl-ADP-ribose deacetylase	-
AC20117_RS10025	2116281..2117111	-	831	WP_074699849.1	FRG domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10065.50 Da
• Isoelectric Point: 8.0657

>T70727 WP_074699855.1 NZ_CP018863:2112550-2112804 [Arthrobacter crystallopoietes]
VNVLFTDIGWQDYQYWLATDRAILKRINRLIEECRRTPFEGIGKPEALKHQLAGYWSRRITEEHRLVYAVEENQLVVIAA
RHHY

Nucleotide

• Length: 255 bp

>T70727 NZ_CP018863:2112550-2112804 [Arthrobacter crystallopoietes]
GTGAATGTGCTGTTTACCGACATCGGTTGGCAGGATTACCAATACTGGCTCGCAACGGACAGGGCCATCCTGAAGCGCAT
CAACCGGCTAATTGAGGAATGCCGGCGCACTCCGTTCGAGGGCATTGGCAAGCCGGAAGCGCTTAAGCACCAACTGGCGG
GATACTGGTCACGCCGGATCACCGAAGAACACAGGCTGGTCTACGCCGTGGAGGAGAACCAGTTAGTGGTCATCGCCGCC
CGCCATCACTACTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8804.01 Da
• Isoelectric Point: 5.6746

>AT70727 WP_074699856.1 NZ_CP018863:2112308-2112553 [Arthrobacter crystallopoietes]
MAITASEARARLFPLIEQVNEDHAPVEIVSKKGSAVLMSLEDYEALQETAYLLRTPANAARLTESIAQHRAGKAAARQLA
E

Nucleotide

• Length: 246 bp

>AT70727 NZ_CP018863:2112308-2112553 [Arthrobacter crystallopoietes]
ATGGCCATAACCGCATCGGAAGCACGCGCGCGCCTCTTTCCCCTGATCGAACAGGTCAACGAGGACCATGCCCCCGTTGA
AATCGTGTCGAAAAAGGGCAGCGCAGTGCTCATGTCGCTTGAAGATTACGAGGCCTTGCAGGAGACGGCATACCTGCTGC
GTACCCCCGCAAACGCCGCCCGCCTTACCGAAAGCATTGCCCAGCATCGGGCCGGAAAAGCAGCAGCCAGGCAGCTCGCC
GAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1H1BM97