Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3724904..3725571 Replicon chromosome
Accession NZ_CP018858
Organism Xanthomonas citri pv. citri strain LH201

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag BJD09_RS16965 Protein ID WP_005916679.1
Coordinates 3724904..3725320 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag BJD09_RS16970 Protein ID WP_005916676.1
Coordinates 3725317..3725571 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BJD09_RS16945 3720759..3721085 + 327 Protein_3142 hypothetical protein -
BJD09_RS16950 3721114..3721545 - 432 WP_005922907.1 hypothetical protein -
BJD09_RS16955 3721861..3722259 + 399 WP_004429277.1 DUF2384 domain-containing protein -
BJD09_RS16960 3722363..3723982 - 1620 WP_015463800.1 hypothetical protein -
BJD09_RS25765 3724239..3724451 + 213 WP_015472901.1 hypothetical protein -
BJD09_RS25770 3724570..3724782 + 213 WP_015472900.1 hypothetical protein -
BJD09_RS16965 3724904..3725320 - 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
BJD09_RS16970 3725317..3725571 - 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
BJD09_RS16975 3725717..3726823 - 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
BJD09_RS16980 3726810..3727016 - 207 WP_003489327.1 hypothetical protein -
BJD09_RS16985 3727255..3727782 + 528 WP_005916668.1 hypothetical protein -
BJD09_RS16990 3727808..3729073 - 1266 WP_015463799.1 cardiolipin synthase B -
BJD09_RS16995 3729230..3729449 - 220 Protein_3154 RNA 2'-phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T70722 WP_005916679.1 NZ_CP018858:c3725320-3724904 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T70722 NZ_CP018858:c3725320-3724904 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT70722 WP_005916676.1 NZ_CP018858:c3725571-3725317 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT70722 NZ_CP018858:c3725571-3725317 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References