Detailed information of TA system TA070712

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 412167..412711
• Replicon: chromosome
• Accession: NZ_CP018854
• Organism: Xanthomonas citri pv. citri strain LH276

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H8FI26
• Locus tag: BI316_RS01740
• Protein ID: WP_003487886.1
• Coordinates: 412412..412711 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H8FI25
• Locus tag: BI316_RS01735
• Protein ID: WP_003487884.1
• Coordinates: 412167..412424 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BI316_RS01720	407292..408767	-	1476	WP_058958536.1	ribonuclease H-like domain-containing protein	-
BI316_RS01725	408764..411259	-	2496	WP_015462699.1	DEAD/DEAH box helicase	-
BI316_RS01730	411437..412099	+	663	WP_005912558.1	hemolysin III family protein	-
BI316_RS01735	412167..412424	+	258	WP_003487884.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BI316_RS01740	412412..412711	+	300	WP_003487886.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BI316_RS01750	412891..413790	-	900	WP_011050073.1	SDR family NAD(P)-dependent oxidoreductase	-
BI316_RS01755	413850..414587	-	738	WP_003487890.1	SDR family oxidoreductase	-
BI316_RS01760	414713..415624	+	912	WP_011050074.1	LysR family transcriptional regulator	-
BI316_RS01765	415790..416863	-	1074	WP_040107715.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11231.97 Da
• Isoelectric Point: 9.7235

>T70712 WP_003487886.1 NZ_CP018854:412412-412711 [Xanthomonas citri pv. citri]
MAEIIWSVPALADLDAIADYIAIDNAPAAAALVKRVFGHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRI
VVVHVMRSERALRGNRLSR

Nucleotide

• Length: 300 bp

>T70712 NZ_CP018854:412412-412711 [Xanthomonas citri pv. citri]
ATGGCTGAAATAATCTGGTCGGTGCCGGCATTGGCTGATCTGGACGCAATTGCCGACTACATCGCAATCGATAACGCACC
CGCTGCAGCGGCGCTGGTGAAACGGGTGTTCGGGCACGTTGAGCAATTGATCGAACACCCGGACAGCGGAAGCCGACCAC
AGGAACTCAAGCGCTCGCGCTATCGCCAGATTGTCGAACCACCTTGCCGCGTGTTCTACCGCGTGGATGGGCAGCGCATC
GTGGTGGTGCACGTCATGCGGTCGGAGCGCGCGCTTCGCGGGAACCGTCTTTCACGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9683.21 Da
• Isoelectric Point: 9.8274

>AT70712 WP_003487884.1 NZ_CP018854:412167-412424 [Xanthomonas citri pv. citri]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVAEGRTLSHEQARHRM
ARWLK

Nucleotide

• Length: 258 bp

>AT70712 NZ_CP018854:412167-412424 [Xanthomonas citri pv. citri]
ATGCGCACCGAACTTGTCACCACGCTCAAGCGTCAGGCGACCGAACTCCTTGCAGCTGCAGAGCGCGACAAGGAGCCAAT
CCTGATCACACAGCACGGTTTACCCAGTGCCTATCTGGTGGATGTTGCCAGCTATGAGCGCATGCAGCAGCGCATTGCGC
TCCTCGAAGGAATCGCCCGTGGAGAAATGGCAGTCGCGGAAGGCCGTACGCTGAGCCATGAACAGGCACGGCACCGCATG
GCGCGATGGCTGAAATAA

Structures

Toxin

• AlphaFold DB: H8FI26

Antitoxin

• AlphaFold DB: H8FI25