Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2906842..2907509 Replicon chromosome
Accession NZ_CP018850
Organism Xanthomonas citri pv. citri strain LJ207-7

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag BI315_RS12945 Protein ID WP_005916679.1
Coordinates 2907093..2907509 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag BI315_RS12940 Protein ID WP_005916676.1
Coordinates 2906842..2907096 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI315_RS12915 2902964..2903183 + 220 Protein_2370 RNA 2'-phosphotransferase -
BI315_RS12920 2903340..2904605 + 1266 WP_015463799.1 cardiolipin synthase B -
BI315_RS12925 2904631..2905158 - 528 WP_005916668.1 hypothetical protein -
BI315_RS12930 2905397..2905603 + 207 WP_003489327.1 hypothetical protein -
BI315_RS12935 2905590..2906696 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
BI315_RS12940 2906842..2907096 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
BI315_RS12945 2907093..2907509 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
BI315_RS25920 2907631..2907903 - 273 WP_125459513.1 hypothetical protein -
BI315_RS25925 2907962..2908174 - 213 WP_015472901.1 hypothetical protein -
BI315_RS12950 2908431..2910050 + 1620 WP_015463800.1 hypothetical protein -
BI315_RS12955 2910154..2910552 - 399 WP_004429277.1 DUF2384 domain-containing protein -
BI315_RS12960 2910868..2911299 + 432 WP_005922907.1 hypothetical protein -
BI315_RS12965 2911328..2911654 - 327 Protein_2382 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T70706 WP_005916679.1 NZ_CP018850:2907093-2907509 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T70706 NZ_CP018850:2907093-2907509 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT70706 WP_005916676.1 NZ_CP018850:2906842-2907096 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT70706 NZ_CP018850:2906842-2907096 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References