Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 428788..429455 Replicon chromosome
Accession NZ_CP018847
Organism Xanthomonas citri pv. citri strain LL074-4

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag BI314_RS01970 Protein ID WP_005916679.1
Coordinates 428788..429204 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag BI314_RS01975 Protein ID WP_005916676.1
Coordinates 429201..429455 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BI314_RS01950 424643..424969 + 327 Protein_354 hypothetical protein -
BI314_RS01955 424998..425429 - 432 WP_005922907.1 hypothetical protein -
BI314_RS01960 425745..426143 + 399 WP_004429277.1 DUF2384 domain-containing protein -
BI314_RS01965 426247..427866 - 1620 WP_015463800.1 hypothetical protein -
BI314_RS25410 428123..428335 + 213 WP_015472901.1 hypothetical protein -
BI314_RS25415 428463..428666 + 204 WP_125460668.1 hypothetical protein -
BI314_RS01970 428788..429204 - 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
BI314_RS01975 429201..429455 - 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
BI314_RS01980 429601..430707 - 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
BI314_RS01985 430694..430900 - 207 WP_003489327.1 hypothetical protein -
BI314_RS01990 431139..431666 + 528 WP_005916668.1 hypothetical protein -
BI314_RS01995 431692..432957 - 1266 WP_015463799.1 cardiolipin synthase B -
BI314_RS02000 433114..433333 - 220 Protein_366 RNA 2'-phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T70697 WP_005916679.1 NZ_CP018847:c429204-428788 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T70697 NZ_CP018847:c429204-428788 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT70697 WP_005916676.1 NZ_CP018847:c429455-429201 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT70697 NZ_CP018847:c429455-429201 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References