Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 509108..509739 Replicon chromosome
Accession NZ_CP018846
Organism Pseudomonas putida strain AA7

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BUQ73_RS02380 Protein ID WP_079226515.1
Coordinates 509108..509335 (+) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BUQ73_RS02385 Protein ID WP_060485575.1
Coordinates 509332..509739 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUQ73_RS02355 505444..506421 - 978 WP_079226511.1 hypothetical protein -
BUQ73_RS02360 506432..506920 - 489 WP_079226512.1 type VI secretion system tube protein Hcp -
BUQ73_RS02365 507218..507562 - 345 WP_003258412.1 cupin domain-containing protein -
BUQ73_RS02370 507659..508588 - 930 WP_079226513.1 CDF family Co(II)/Ni(II) efflux transporter DmeF -
BUQ73_RS02375 508659..508934 + 276 WP_079226514.1 metal/formaldehyde-sensitive transcriptional repressor -
BUQ73_RS02380 509108..509335 + 228 WP_079226515.1 type II toxin-antitoxin system HicA family toxin Toxin
BUQ73_RS02385 509332..509739 + 408 WP_060485575.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BUQ73_RS02390 509850..510734 - 885 WP_079226516.1 LysR family transcriptional regulator -
BUQ73_RS02395 510813..511577 + 765 WP_079230468.1 sulfite exporter TauE/SafE family protein -
BUQ73_RS02400 511567..511881 - 315 WP_027918390.1 antibiotic biosynthesis monooxygenase -
BUQ73_RS02405 512040..512630 + 591 WP_079226517.1 NAD(P)H-dependent oxidoreductase -
BUQ73_RS02410 512661..513557 + 897 WP_079226518.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8322.39 Da        Isoelectric Point: 10.2063

>T70693 WP_079226515.1 NZ_CP018846:509108-509335 [Pseudomonas putida]
MRSREVIQLIEADGWYEAEVKGSHHQFRHPMKKGRVTVPHPKSDLPKGTVHSILKQAGLKQSSGFDSSNISGDAQ

Download         Length: 228 bp

>T70693 NZ_CP018846:509108-509335 [Pseudomonas putida]
ATGCGCAGTCGTGAAGTGATCCAGCTCATTGAGGCGGACGGGTGGTACGAGGCCGAGGTCAAGGGCAGCCATCACCAGTT
CAGGCACCCGATGAAGAAGGGGAGGGTGACAGTTCCTCATCCCAAGAGCGATCTTCCTAAAGGCACCGTACACAGCATCC
TGAAGCAAGCTGGCTTGAAGCAGTCCAGTGGCTTCGATAGCTCGAACATCAGTGGAGACGCGCAATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14605.40 Da        Isoelectric Point: 4.7169

>AT70693 WP_060485575.1 NZ_CP018846:509332-509739 [Pseudomonas putida]
MKFPVVLHKDADSDYGVTVPDVPGCFSAGSTVAQALENVQEALALHFEGLVADNEALPQAQEVDVHVANSDYAGGVWAVV
DFDVTPYLGKAVRFNATLPENLLQRIDEKVKRDHRYASRSGFLASAALRELALAH

Download         Length: 408 bp

>AT70693 NZ_CP018846:509332-509739 [Pseudomonas putida]
ATGAAATTCCCGGTCGTATTGCACAAGGACGCCGATTCGGATTATGGCGTGACCGTTCCCGACGTGCCTGGTTGCTTCTC
TGCGGGCTCGACTGTCGCCCAGGCGCTGGAGAACGTTCAAGAGGCGCTAGCGCTGCATTTTGAGGGTTTGGTTGCTGATA
ACGAAGCGCTTCCTCAAGCGCAGGAAGTCGACGTCCATGTGGCGAATTCCGATTATGCTGGCGGGGTCTGGGCTGTCGTT
GATTTCGATGTCACGCCTTACTTGGGGAAGGCCGTGCGGTTCAACGCAACATTGCCGGAAAACCTCCTTCAGCGGATCGA
TGAAAAAGTGAAGCGTGACCATCGGTATGCTTCTCGTTCTGGATTTCTCGCGTCGGCCGCTCTAAGAGAACTGGCGCTCG
CACACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References