Detailed information of TA system TA070691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1681940..1682410
• Replicon: chromosome
• Accession: NZ_CP018842
• Organism: Staphylococcus epidermidis strain 14.1.R1

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A939NNQ7
• Locus tag: BUM85_RS08430
• Protein ID: WP_002445998.1
• Coordinates: 1682222..1682410 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A829M688
• Locus tag: BUM85_RS08425
• Protein ID: WP_002445999.1
• Coordinates: 1681940..1682197 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BUM85_RS08385	1677207..1677749	-	543	WP_002475966.1	nitroreductase	-
BUM85_RS08390	1677830..1678546	-	717	WP_002475962.1	type I 3-dehydroquinate dehydratase	-
BUM85_RS08395	1678707..1679129	+	423	WP_002457221.1	organic hydroperoxide resistance protein	-
BUM85_RS08400	1679323..1679451	+	129	WP_002446004.1	hypothetical protein	-
BUM85_RS08405	1679535..1680035	+	501	WP_002446003.1	GNAT family N-acetyltransferase	-
BUM85_RS08410	1680306..1680872	-	567	WP_083324152.1	histidine phosphatase family protein	-
BUM85_RS08415	1681107..1681343	+	237	WP_002446001.1	hypothetical protein	-
BUM85_RS08420	1681335..1681538	-	204	WP_002446000.1	sterile alpha motif-like domain-containing protein	-
BUM85_RS08425	1681940..1682197	+	258	WP_002445999.1	hypothetical protein	Antitoxin
BUM85_RS08430	1682222..1682410	+	189	WP_002445998.1	hypothetical protein	Toxin
BUM85_RS08435	1682599..1683153	+	555	WP_002475968.1	hypothetical protein	-
BUM85_RS08440	1683212..1683448	-	237	WP_002475965.1	hypothetical protein	-
BUM85_RS08445	1683659..1684405	+	747	WP_002457228.1	poly-gamma-glutamate hydrolase family protein	-
BUM85_RS08450	1684504..1684788	+	285	WP_001829635.1	hypothetical protein	-
BUM85_RS08455	1684813..1685037	+	225	WP_002474944.1	hypothetical protein	-
BUM85_RS08460	1685655..1685855	-	201	WP_001829681.1	cold-shock protein	-
BUM85_RS08465	1686752..1686826	+	75	WP_095658922.1	epsilon family phenol-soluble modulin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (83-134)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7257.95 Da
• Isoelectric Point: 9.8369

>T70691 WP_002445998.1 NZ_CP018842:1682222-1682410 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKREERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T70691 NZ_CP018842:1682222-1682410 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAGAGAAGAACGAAAAGAATCTTATCTAGGTTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT70691 WP_002445999.1 NZ_CP018842:1681940-1682197 [Staphylococcus epidermidis]
MKLNKANVFNLIFTILFFTFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT70691 NZ_CP018842:1681940-1682197 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATGTATTCAACTTGATATTCACCATTTTATTTTTTACATTTAACATTCTCATAACCTATAA
CGCAAATATTGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGCTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTATATTATATTTATCCGATT
TTTTATGAATTTGTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A829M688