Detailed information of TA system TA070687

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 660816..661621
• Replicon: chromosome
• Accession: NZ_CP018842
• Organism: Staphylococcus epidermidis strain 14.1.R1

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: BUM85_RS03510
• Protein ID: WP_002457885.1
• Coordinates: 661439..661621 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A0E1VBD1
• Locus tag: BUM85_RS03505
• Protein ID: WP_002446763.1
• Coordinates: 660816..661415 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BUM85_RS03485	656528..657985	+	1458	WP_102841582.1	ABC transporter substrate-binding protein/permease	-
BUM85_RS03490	657972..658700	+	729	WP_023474047.1	amino acid ABC transporter ATP-binding protein	-
BUM85_RS03495	659049..660191	+	1143	WP_002446765.1	tRNA epoxyqueuosine(34) reductase QueG	-
BUM85_RS03500	660188..660658	+	471	WP_002446764.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
BUM85_RS03505	660816..661415	+	600	WP_002446763.1	glucosamine-6-phosphate isomerase	Antitoxin
BUM85_RS03510	661439..661621	+	183	WP_002457885.1	hypothetical protein	Toxin
BUM85_RS03515	661773..662177	+	405	WP_002446761.1	hypothetical protein	-
BUM85_RS03520	662369..663754	+	1386	WP_002476049.1	class II fumarate hydratase	-
BUM85_RS03525	664229..664711	+	483	Protein_660	transposase	-
BUM85_RS03530	664885..665709	-	825	WP_002457882.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	664400..664711	311

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7080.67 Da
• Isoelectric Point: 4.3016

>T70687 WP_002457885.1 NZ_CP018842:661439-661621 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQPHDNEVRSDFKNSK

Nucleotide

• Length: 183 bp

>T70687 NZ_CP018842:661439-661621 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAACGCTATGGTGACTGATTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAAATTTCACAGGAGAATGATGAAGAAAAATTAAATCAACCTCATGATAACGAAGTTCGTT
CAGATTTTAAAAATAGTAAATAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22635.54 Da
• Isoelectric Point: 4.9942

>AT70687 WP_002446763.1 NZ_CP018842:660816-661415 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLGKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDVSVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT70687 NZ_CP018842:660816-661415 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGACAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTAGGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTGG
AAAATCATGCAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAAGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCAATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAGGGAAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGCAAACTTGACGTTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACCGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAGAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A0E1VBD1