Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 492747..493256 Replicon chromosome
Accession NZ_CP018842
Organism Staphylococcus epidermidis strain 14.1.R1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0E1VPY9
Locus tag BUM85_RS02500 Protein ID WP_002447767.1
Coordinates 493047..493256 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A829M395
Locus tag BUM85_RS02495 Protein ID WP_002458700.1
Coordinates 492747..493040 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUM85_RS02470 487755..488543 + 789 WP_002475462.1 hydroxyethylthiazole kinase -
BUM85_RS02475 488549..489187 + 639 WP_002458704.1 thiamine phosphate synthase -
BUM85_RS02480 489276..490148 + 873 WP_002458703.1 membrane protein insertase YidC -
BUM85_RS02485 490255..490908 - 654 WP_002475468.1 HD domain-containing protein -
BUM85_RS02490 491090..492573 - 1484 Protein_488 cardiolipin synthase -
BUM85_RS02495 492747..493040 + 294 WP_002458700.1 copper-sensing transcriptional repressor CsoR Antitoxin
BUM85_RS02500 493047..493256 + 210 WP_002447767.1 cation transporter Toxin
BUM85_RS02505 493400..493537 + 138 WP_001829949.1 hypothetical protein -
BUM85_RS02510 493636..494847 - 1212 WP_002447766.1 rod shape-determining protein RodA -
BUM85_RS02515 495238..496311 + 1074 WP_002458698.1 D-alanine--D-alanine ligase -
BUM85_RS02520 496323..497678 + 1356 WP_002447764.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(10-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 8008.28 Da        Isoelectric Point: 6.4556

>T70685 WP_002447767.1 NZ_CP018842:493047-493256 [Staphylococcus epidermidis]
MKLKKGLIHVSGIKTTEQEKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDCGFRIL

Download         Length: 210 bp

>T70685 NZ_CP018842:493047-493256 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATACATGTTTCAGGTATTAAAACAACTGAACAAGAGAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTGGAATTTGACACTCCCGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTGCGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11082.71 Da        Isoelectric Point: 5.5778

>AT70685 WP_002458700.1 NZ_CP018842:492747-493040 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVAIKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT70685 NZ_CP018842:492747-493040 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATCAATCGTATGATTGATGACGATGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTATTAAATTACTAGATCATCACATGAAGGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VPY9

Antitoxin

Source ID Structure
AlphaFold DB A0A829M395

References