Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 1471944..1472446 Replicon chromosome
Accession NZ_CP018839
Organism Thauera chlorobenzoica strain 3CB1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2R4BRX9
Locus tag Tchl_RS06950 Protein ID WP_075147756.1
Coordinates 1471944..1472198 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1H5T930
Locus tag Tchl_RS06955 Protein ID WP_075147757.1
Coordinates 1472195..1472446 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tchl_RS06930 1467722..1468951 + 1230 WP_075147752.1 CoA transferase -
Tchl_RS06935 1469070..1470290 + 1221 WP_075147753.1 acyl-CoA dehydrogenase -
Tchl_RS06940 1470329..1471099 + 771 WP_075147754.1 enoyl-CoA hydratase/isomerase family protein -
Tchl_RS06945 1471167..1471796 + 630 WP_075147755.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
Tchl_RS06950 1471944..1472198 - 255 WP_075147756.1 Txe/YoeB family addiction module toxin Toxin
Tchl_RS06955 1472195..1472446 - 252 WP_075147757.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Tchl_RS06960 1472563..1474134 - 1572 WP_075147758.1 amidohydrolase family protein -
Tchl_RS06965 1474131..1475075 - 945 WP_075147759.1 SDR family oxidoreductase -
Tchl_RS06970 1475098..1476021 - 924 WP_075147760.1 DUF4037 domain-containing protein -
Tchl_RS06975 1476018..1476602 - 585 WP_075147761.1 YgiT-type zinc finger protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10166.73 Da        Isoelectric Point: 9.8954

>T70662 WP_075147756.1 NZ_CP018839:c1472198-1471944 [Thauera chlorobenzoica]
MKLIFAEAAWEDYLHWQQQDRRMVERINKLIRETQREPFSGIGKPEPLKHALAGFWSRRITDEHRMVYRIAGDALLIAQL
RYHY

Download         Length: 255 bp

>T70662 NZ_CP018839:c1472198-1471944 [Thauera chlorobenzoica]
ATGAAGTTGATCTTCGCCGAGGCCGCTTGGGAAGATTACCTTCATTGGCAGCAACAAGACCGGCGCATGGTGGAGCGGAT
CAACAAGCTCATTCGCGAAACTCAGCGTGAACCTTTTTCCGGTATCGGCAAACCTGAACCGCTCAAACACGCCCTGGCGG
GATTTTGGTCCAGGCGGATTACCGACGAGCATCGGATGGTGTACAGAATCGCCGGCGACGCGTTGCTGATCGCTCAGTTG
CGCTACCACTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9023.07 Da        Isoelectric Point: 4.1677

>AT70662 WP_075147757.1 NZ_CP018839:c1472446-1472195 [Thauera chlorobenzoica]
MDAISYTAARANLASTMDRVCNDHEPLIITRSGQASVVMLSLDDFQALEETAYLLRSPENARRLLGAIAELNAGGGNERE
LDE

Download         Length: 252 bp

>AT70662 NZ_CP018839:c1472446-1472195 [Thauera chlorobenzoica]
ATGGACGCCATTTCCTACACCGCAGCCCGGGCCAATCTGGCCAGTACGATGGACCGCGTCTGCAACGACCACGAGCCGCT
GATCATTACCCGTAGCGGGCAAGCCTCGGTCGTCATGCTTTCCCTCGACGACTTCCAGGCCCTCGAGGAAACCGCCTACC
TGTTGCGCAGCCCCGAGAATGCGCGCCGCCTGCTCGGCGCCATAGCCGAACTCAATGCCGGCGGAGGCAACGAGCGGGAA
CTCGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R4BRX9

Antitoxin

Source ID Structure
AlphaFold DB A0A1H5T930

References