Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 873888..874413 Replicon chromosome
Accession NZ_CP018839
Organism Thauera chlorobenzoica strain 3CB1

Toxin (Protein)


Gene name relE Uniprot ID A0A1H5U558
Locus tag Tchl_RS04170 Protein ID WP_075147287.1
Coordinates 873888..874166 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1H5U5K9
Locus tag Tchl_RS04175 Protein ID WP_075147288.1
Coordinates 874156..874413 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tchl_RS04145 869045..869698 + 654 WP_075147283.1 protein-L-isoaspartate O-methyltransferase -
Tchl_RS04150 869714..870037 + 324 WP_075147284.1 sulfurtransferase -
Tchl_RS04155 870066..871391 + 1326 WP_075147285.1 TolC family outer membrane protein -
Tchl_RS04160 871447..872739 - 1293 WP_075149566.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
Tchl_RS04165 873022..873819 + 798 WP_075147286.1 symmetrical bis(5'-nucleosyl)-tetraphosphatase -
Tchl_RS04170 873888..874166 - 279 WP_075147287.1 Txe/YoeB family addiction module toxin Toxin
Tchl_RS04175 874156..874413 - 258 WP_075147288.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Tchl_RS04180 874436..875347 - 912 WP_198159044.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
Tchl_RS04185 875401..876180 - 780 WP_075147289.1 GNAT family N-acetyltransferase -
Tchl_RS04190 876346..877281 + 936 WP_075147290.1 carbohydrate kinase family protein -
Tchl_RS04195 877275..877748 + 474 WP_075147291.1 glycine zipper 2TM domain-containing protein -
Tchl_RS04200 877789..878639 - 851 Protein_826 zinc-ribbon and DUF3426 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11014.65 Da        Isoelectric Point: 7.8747

>T70660 WP_075147287.1 NZ_CP018839:c874166-873888 [Thauera chlorobenzoica]
MPIEEKPLRLTWTLAAWEDYEYWQGQDRKTLKRINALIKDGLRHPFEGIGKPEPLKENLAGFWSRRIDDTHRLVYCVDDR
ALVVIACRYHYQ

Download         Length: 279 bp

>T70660 NZ_CP018839:c874166-873888 [Thauera chlorobenzoica]
ATGCCGATTGAAGAAAAGCCGCTCAGGCTGACCTGGACCCTGGCTGCCTGGGAGGATTACGAATACTGGCAAGGCCAGGA
CCGCAAAACCCTCAAACGCATCAATGCCCTGATCAAGGACGGCTTGCGCCACCCCTTCGAAGGCATCGGCAAACCCGAGC
CCCTGAAAGAAAACCTGGCGGGCTTCTGGTCACGCCGCATCGACGACACCCACCGGCTGGTGTACTGCGTCGACGATCGG
GCGCTGGTGGTGATCGCCTGTCGTTACCACTACCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9495.69 Da        Isoelectric Point: 4.9878

>AT70660 WP_075147288.1 NZ_CP018839:c874413-874156 [Thauera chlorobenzoica]
MRVVNFSEARNNLKNVIDQVIDDADYTVIARRDAPNAVVMSLDTFNGLMETVHLLKSPANAAHLARSIEQYRQGQVTPRD
LVDAD

Download         Length: 258 bp

>AT70660 NZ_CP018839:c874413-874156 [Thauera chlorobenzoica]
ATGCGTGTAGTGAATTTTTCGGAGGCGCGGAACAACCTCAAGAACGTGATCGATCAGGTCATCGACGACGCCGACTACAC
GGTCATCGCGCGCCGGGATGCGCCCAATGCGGTGGTGATGTCGCTCGACACCTTCAACGGCTTGATGGAGACCGTCCATC
TACTGAAGTCCCCCGCCAATGCCGCCCACCTGGCACGCTCGATCGAGCAGTACCGCCAGGGCCAGGTCACGCCGCGGGAT
CTGGTCGATGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H5U558

Antitoxin

Source ID Structure
AlphaFold DB A0A1H5U5K9

References