Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 604185..605724 Replicon chromosome
Accession NZ_CP018839
Organism Thauera chlorobenzoica strain 3CB1

Toxin (Protein)


Gene name HipA1 Uniprot ID A0A1H5XL29
Locus tag Tchl_RS02950 Protein ID WP_075147074.1
Coordinates 604185..605474 (-) Length 430 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID A0A1H5XM71
Locus tag Tchl_RS02955 Protein ID WP_075147075.1
Coordinates 605464..605724 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tchl_RS02930 599670..601547 + 1878 WP_075147070.1 ABC transporter ATP-binding protein/permease -
Tchl_RS02935 601575..602192 - 618 WP_075147071.1 hypothetical protein -
Tchl_RS02940 602346..602951 + 606 WP_075147072.1 DUF938 domain-containing protein -
Tchl_RS02945 603000..604061 + 1062 WP_075147073.1 MBL fold metallo-hydrolase -
Tchl_RS02950 604185..605474 - 1290 WP_075147074.1 type II toxin-antitoxin system HipA family toxin Toxin
Tchl_RS02955 605464..605724 - 261 WP_075147075.1 helix-turn-helix transcriptional regulator Antitoxin
Tchl_RS02965 606216..607916 + 1701 WP_075147077.1 IS1634 family transposase -
Tchl_RS02970 608183..609016 + 834 WP_075147078.1 DUF3037 domain-containing protein -
Tchl_RS02980 609460..609738 + 279 WP_075149545.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 606216..607916 1700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(147-377)

Antitoxin

Transcription regulator, HipB-like

(8-65)


Sequences

Toxin        


Download         Length: 430 a.a.        Molecular weight: 47412.33 Da        Isoelectric Point: 7.2425

>T70659 WP_075147074.1 NZ_CP018839:c605474-604185 [Thauera chlorobenzoica]
MAHELEVWLFADRVGSLYLTEGRLNFRYNPDWLSRPDAVTLSSSFPLQAEAFDDHQTRPFFAGLLPEGQLRRLIAQHFQV
SRQNDFALLDHIGGECAGAVTLLAPGQALSRPAPGNDVQWLSDEEIIAVLDELPHRPMLAGKEGLRLSLAGAQDKLPVIF
DGARVGLPLDGTPSSHILKPAIRTLEDTVTNEGFCLALAEVMQLKPARSKVHSVLGRQFLLVERYDRFIDAQGHRQRLHQ
EDFCQALGVVPEMKYQHEGGPDLAQCFDLVRRMTRPSAPHVLRLLDYVIFNALIGNHDAHAKNFSLLRAGKSAVLAPLYD
TLSTAVYPALTHKMAMKIGGKYTFSEVQARHWDQFAEAVRLGKAQARKRVLALAKSLPTSARELHSQDGFAGHAVVERIV
TLIEQRCALTVRRLSAPGADAGVETEPVA

Download         Length: 1290 bp

>T70659 NZ_CP018839:c605474-604185 [Thauera chlorobenzoica]
ATGGCGCATGAGCTGGAGGTCTGGCTGTTCGCGGACCGGGTTGGCTCTCTGTACCTGACCGAGGGCCGGCTGAATTTCCG
TTACAACCCGGACTGGCTCTCACGACCAGACGCCGTGACCTTGTCCAGCTCCTTTCCTCTGCAAGCAGAAGCGTTCGACG
ACCATCAGACCCGGCCCTTCTTTGCGGGGTTGTTGCCGGAGGGGCAGCTGCGCAGACTCATTGCGCAGCACTTTCAGGTA
TCGAGGCAGAACGATTTTGCACTGCTGGATCACATCGGCGGCGAATGTGCCGGCGCCGTGACCTTGCTGGCGCCCGGGCA
GGCATTGTCCCGTCCTGCGCCGGGTAACGATGTACAGTGGCTGAGCGACGAAGAGATCATCGCCGTTCTTGATGAACTGC
CGCATCGACCAATGCTGGCGGGCAAGGAGGGCTTGCGGCTCTCGCTGGCGGGCGCTCAAGACAAATTGCCGGTGATCTTC
GACGGTGCCCGGGTGGGTCTGCCGCTCGATGGTACCCCCAGCTCACACATCCTGAAGCCCGCCATCCGCACCCTTGAAGA
CACGGTGACCAACGAGGGCTTCTGTCTGGCGCTGGCCGAGGTCATGCAACTCAAACCGGCCAGATCGAAGGTGCATTCCG
TACTGGGCCGACAGTTCCTGCTGGTCGAGCGCTACGACCGGTTCATCGATGCGCAAGGGCACCGCCAGCGCCTGCATCAG
GAGGACTTCTGCCAGGCGCTGGGCGTGGTCCCGGAGATGAAATACCAGCACGAAGGCGGCCCGGATCTGGCGCAATGTTT
CGATCTGGTCCGGCGCATGACGCGCCCCAGCGCGCCGCACGTCCTGCGCCTGCTCGACTACGTGATCTTCAACGCCTTGA
TCGGCAATCACGACGCACACGCGAAGAATTTTTCGCTGCTGCGCGCAGGCAAGTCCGCCGTGCTGGCGCCTTTGTACGAC
ACGCTGTCGACAGCGGTCTATCCGGCCCTGACGCACAAGATGGCGATGAAAATCGGCGGCAAGTACACGTTCAGCGAAGT
CCAGGCGCGCCACTGGGATCAGTTTGCCGAAGCAGTTCGACTCGGCAAGGCGCAAGCCAGAAAGCGGGTTCTGGCCTTGG
CAAAGTCATTGCCGACGAGCGCGCGCGAACTTCACTCCCAGGATGGCTTTGCCGGTCATGCCGTGGTTGAGCGAATCGTG
ACCCTGATCGAGCAGCGCTGCGCCCTGACGGTACGAAGGCTCAGCGCTCCCGGCGCTGACGCGGGAGTTGAGACCGAGCC
AGTGGCATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9106.42 Da        Isoelectric Point: 7.3204

>AT70659 WP_075147075.1 NZ_CP018839:c605724-605464 [Thauera chlorobenzoica]
MDSIRTTEQLGHALRAARKQLGLTQPQLALAAGVGVRFIVDLEAGKPTLRLENVLRVIDALGGELQLTGLPSTAREHFPG
GNDHGA

Download         Length: 261 bp

>AT70659 NZ_CP018839:c605724-605464 [Thauera chlorobenzoica]
ATGGACTCCATACGAACAACAGAACAACTCGGCCACGCACTTCGTGCTGCACGCAAGCAGCTGGGTCTGACGCAGCCCCA
GCTGGCTCTGGCGGCAGGCGTTGGTGTGCGTTTCATCGTCGACCTTGAAGCAGGCAAGCCCACCCTGAGGCTGGAAAACG
TGCTTCGCGTGATCGACGCCCTGGGTGGAGAGCTCCAACTCACCGGCCTGCCATCGACGGCCCGCGAACATTTCCCCGGG
GGCAACGACCATGGCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H5XL29

Antitoxin

Source ID Structure
AlphaFold DB A0A1H5XM71

References