Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 233549..234139 Replicon chromosome
Accession NZ_CP018839
Organism Thauera chlorobenzoica strain 3CB1

Toxin (Protein)


Gene name relE Uniprot ID A0A1H5Z0C4
Locus tag Tchl_RS01080 Protein ID WP_075146760.1
Coordinates 233840..234139 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1H5YZN8
Locus tag Tchl_RS01075 Protein ID WP_075146759.1
Coordinates 233549..233836 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tchl_RS01055 228752..230134 + 1383 WP_075146755.1 FAD-binding oxidoreductase -
Tchl_RS01060 230288..232552 + 2265 WP_075146756.1 OsmC domain/YcaO domain-containing protein -
Tchl_RS01065 232567..232947 - 381 WP_198158976.1 type II toxin-antitoxin system PemK/MazF family toxin -
Tchl_RS01070 232944..233195 - 252 WP_075146758.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
Tchl_RS01075 233549..233836 - 288 WP_075146759.1 putative addiction module antidote protein Antitoxin
Tchl_RS01080 233840..234139 - 300 WP_075146760.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Tchl_RS01090 234582..234785 + 204 WP_075146762.1 YjfB family protein -
Tchl_RS01095 234886..235230 + 345 WP_075146763.1 hypothetical protein -
Tchl_RS01100 235251..235487 + 237 WP_075146764.1 hypothetical protein -
Tchl_RS01105 235644..236078 - 435 WP_075146765.1 Rrf2 family transcriptional regulator -
Tchl_RS01110 236301..238952 - 2652 WP_075146766.1 anaerobic nitric oxide reductase flavorubredoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-89)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11251.84 Da        Isoelectric Point: 9.5219

>T70656 WP_075146760.1 NZ_CP018839:c234139-233840 [Thauera chlorobenzoica]
MNTFLRTDEFDAWLAGLKDNVARARIIHRIRSAEHGNFGDCEPVGEGVSEMRIHVGPGYRAYYTRRGAVIYLLLLGGDKS
SQKRDIKRAIEMARTLDKE

Download         Length: 300 bp

>T70656 NZ_CP018839:c234139-233840 [Thauera chlorobenzoica]
ATGAACACCTTCCTGCGTACGGACGAGTTCGACGCCTGGCTTGCAGGCTTGAAAGACAACGTGGCACGAGCCCGCATCAT
CCACCGTATCCGCTCTGCTGAACACGGCAATTTCGGTGACTGCGAGCCGGTGGGTGAGGGCGTTTCGGAAATGCGCATCC
ACGTCGGCCCTGGGTACCGCGCTTACTACACGCGACGTGGAGCAGTGATCTATCTGCTTCTGCTGGGCGGGGATAAGTCG
TCGCAAAAGCGCGACATCAAGCGCGCCATCGAGATGGCGCGGACTTTGGACAAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10188.60 Da        Isoelectric Point: 5.6705

>AT70656 WP_075146759.1 NZ_CP018839:c233836-233549 [Thauera chlorobenzoica]
MVKTATFDAADYLNDEETIAEYLTAALEDPNPDVFLSAVRDVARARGMAQLAKDAGLGRESLYKALTPGAKPRYDTVLKL
LHALGVKISATPAHS

Download         Length: 288 bp

>AT70656 NZ_CP018839:c233836-233549 [Thauera chlorobenzoica]
ATGGTCAAGACTGCCACCTTTGACGCTGCCGACTACCTGAACGATGAGGAAACCATCGCAGAGTATCTGACGGCCGCCCT
GGAAGACCCGAACCCTGATGTCTTCCTAAGTGCCGTCCGCGACGTAGCGCGCGCCCGTGGCATGGCGCAGCTCGCCAAGG
ATGCTGGTCTTGGCCGTGAGAGCCTCTACAAAGCGCTCACGCCCGGCGCGAAGCCACGCTATGACACCGTGCTCAAACTG
CTTCATGCGCTGGGCGTGAAGATTTCCGCGACACCAGCGCATTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H5Z0C4

Antitoxin

Source ID Structure
AlphaFold DB A0A1H5YZN8

References