Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 18236..18783 Replicon chromosome
Accession NZ_CP018839
Organism Thauera chlorobenzoica strain 3CB1

Toxin (Protein)


Gene name relE Uniprot ID A0A1H5V9P3
Locus tag Tchl_RS00100 Protein ID WP_075146605.1
Coordinates 18505..18783 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1H5VB05
Locus tag Tchl_RS00095 Protein ID WP_075146604.1
Coordinates 18236..18505 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tchl_RS00070 14752..15084 - 333 WP_075146599.1 type II toxin-antitoxin system RelE/ParE family toxin -
Tchl_RS00075 15081..15332 - 252 WP_075146600.1 addiction module antitoxin -
Tchl_RS00080 15617..15976 - 360 WP_075146601.1 hypothetical protein -
Tchl_RS00085 16197..16808 + 612 WP_075146602.1 hypothetical protein -
Tchl_RS00090 16805..17995 + 1191 WP_075146603.1 DUF2157 domain-containing protein -
Tchl_RS00095 18236..18505 + 270 WP_075146604.1 ribbon-helix-helix domain-containing protein Antitoxin
Tchl_RS00100 18505..18783 + 279 WP_075146605.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Tchl_RS00105 18901..19731 - 831 WP_075146606.1 hypothetical protein -
Tchl_RS00110 19746..20618 - 873 WP_075149504.1 hypothetical protein -
Tchl_RS00120 21234..22526 + 1293 WP_075146608.1 ATP-binding protein -
Tchl_RS00125 22691..23221 + 531 WP_075146609.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10797.61 Da        Isoelectric Point: 10.8700

>T70655 WP_075146605.1 NZ_CP018839:18505-18783 [Thauera chlorobenzoica]
MELKWTRKALADLARLHEFLAPVNRQAAAKAVQALAKAPTILLSNPRIGEQLFQFAPREVRRILVAQYEVRYEIRDSVIY
VLRLWHTREDRT

Download         Length: 279 bp

>T70655 NZ_CP018839:18505-18783 [Thauera chlorobenzoica]
ATGGAGCTGAAGTGGACCCGCAAGGCGCTTGCCGATCTGGCGCGCCTGCATGAGTTCCTGGCGCCGGTGAACAGGCAGGC
CGCCGCGAAGGCGGTACAGGCGCTGGCCAAGGCCCCGACCATCCTGCTGAGCAACCCGCGCATCGGCGAACAGCTCTTCC
AGTTCGCGCCGCGCGAGGTGCGGCGTATCCTGGTCGCGCAGTACGAGGTGCGCTACGAAATCCGCGACTCGGTCATCTAC
GTCCTGCGGCTGTGGCACACCCGAGAGGACCGCACCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9785.23 Da        Isoelectric Point: 4.5388

>AT70655 WP_075146604.1 NZ_CP018839:18236-18505 [Thauera chlorobenzoica]
MTQAATKVLTAHVPLPLAEKVDQMAARLERSRGWIMKQALSAWIAQEEERDRLTQEALADVDAGLVIDPLAVQAWADSLG
TDQPLPLPR

Download         Length: 270 bp

>AT70655 NZ_CP018839:18236-18505 [Thauera chlorobenzoica]
ATGACGCAAGCCGCAACCAAAGTGCTCACCGCCCATGTGCCGCTCCCGCTCGCCGAGAAGGTCGATCAGATGGCCGCGAG
GCTGGAGCGCTCGCGCGGCTGGATCATGAAGCAGGCGCTCTCCGCCTGGATCGCCCAGGAGGAAGAGCGCGACCGCCTGA
CCCAGGAGGCGCTCGCCGACGTGGACGCCGGTCTCGTCATCGACCCTCTCGCGGTGCAGGCCTGGGCCGACAGCCTGGGC
ACCGACCAGCCCCTGCCGCTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H5V9P3

Antitoxin

Source ID Structure
AlphaFold DB A0A1H5VB05

References