Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1159903..1160565 Replicon chromosome
Accession NZ_CP018838
Organism Streptococcus pneumoniae strain 11A

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BUM80_RS06225 Protein ID WP_000192224.1
Coordinates 1160392..1160565 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag BUM80_RS06220 Protein ID WP_000961810.1
Coordinates 1159903..1160355 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUM80_RS06195 1155793..1156536 - 744 WP_001188208.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
BUM80_RS06200 1156538..1157488 - 951 WP_000451131.1 50S ribosomal protein L11 methyltransferase -
BUM80_RS06205 1157626..1158054 - 429 WP_000418156.1 NUDIX hydrolase -
BUM80_RS06210 1158035..1159123 - 1089 WP_000719724.1 M50 family metallopeptidase -
BUM80_RS06215 1159142..1159612 - 471 WP_000257097.1 DUF3013 family protein -
BUM80_RS06220 1159903..1160355 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BUM80_RS06225 1160392..1160565 - 174 WP_000192224.1 type II toxin-antitoxin system HicA family toxin Toxin
BUM80_RS06230 1160708..1160887 - 180 WP_001809903.1 hypothetical protein -
BUM80_RS06240 1161052..1161291 - 240 WP_000818079.1 hypothetical protein -
BUM80_RS06250 1161561..1162832 + 1272 WP_001113216.1 replication-associated recombination protein A -
BUM80_RS06260 1163376..1164695 - 1320 WP_000502554.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6386.51 Da        Isoelectric Point: 10.8214

>T70654 WP_000192224.1 NZ_CP018838:c1160565-1160392 [Streptococcus pneumoniae]
MTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIGKQAGL

Download         Length: 174 bp

>T70654 NZ_CP018838:c1160565-1160392 [Streptococcus pneumoniae]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCATATTAA
AATGGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT70654 WP_000961810.1 NZ_CP018838:c1160355-1159903 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT70654 NZ_CP018838:c1160355-1159903 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References