Detailed information of TA system TA070651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 644994..645510
• Replicon: chromosome
• Accession: NZ_CP018836
• Organism: Vibrio gazogenes strain ATCC 43942

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BSQ33_RS18515
• Protein ID: WP_088134891.1
• Coordinates: 644994..645263 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1M4V2U4
• Locus tag: BSQ33_RS18520
• Protein ID: WP_072955410.1
• Coordinates: 645256..645510 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSQ33_RS18485	640257..640952	-	696	WP_157721438.1	methyltransferase domain-containing protein	-
BSQ33_RS18490	641093..641293	-	201	WP_088134887.1	hypothetical protein	-
BSQ33_RS18495	641389..642012	-	624	WP_088134888.1	hypothetical protein	-
BSQ33_RS18500	642591..643469	-	879	WP_157721439.1	HEPN domain-containing protein	-
BSQ33_RS18505	643749..644246	-	498	WP_021020996.1	GNAT family N-acetyltransferase	-
BSQ33_RS18510	644349..644852	-	504	WP_088134890.1	peptide deformylase	-
BSQ33_RS18515	644994..645263	-	270	WP_088134891.1	Txe/YoeB family addiction module toxin	Toxin
BSQ33_RS18520	645256..645510	-	255	WP_072955410.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BSQ33_RS18525	645657..646112	-	456	WP_072955408.1	hypothetical protein	-
BSQ33_RS18530	646252..646728	-	477	WP_088134892.1	GNAT family N-acetyltransferase	-
BSQ33_RS18535	646865..648196	-	1332	WP_088134893.1	hypothetical protein	-
BSQ33_RS18540	648750..649631	-	882	WP_157721440.1	HEPN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	641389..651141	9752

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10593.00 Da
• Isoelectric Point: 9.8183

>T70651 WP_088134891.1 NZ_CP018836:c645263-644994 [Vibrio gazogenes]
MSSSQRLLSWTDESWNDRLYWQTQNKKTLKRINKLISDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Nucleotide

• Length: 270 bp

>T70651 NZ_CP018836:c645263-644994 [Vibrio gazogenes]
ATGAGTAGTAGCCAGCGATTGCTTTCATGGACTGATGAATCTTGGAATGATCGTTTATATTGGCAAACACAAAATAAAAA
GACATTGAAGCGTATAAATAAATTAATTAGTGATGTAAAACGTTCACCATTTGAAGGTATCGGAAAGCCCGAGCCATTAA
AAGAAAATCTAGCCGGCTTTTGGTCACGCCGTATTGACGACACTAACCGGTTAGTTTATGCGGTTGATGACCAAGCTATC
ACAATTATTTCATGTCGTTATCATTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9444.56 Da
• Isoelectric Point: 4.5700

>AT70651 WP_072955410.1 NZ_CP018836:c645510-645256 [Vibrio gazogenes]
MKIVSFTEARNSLKAVLDGVVNDADTTVITRRDAEDAVVMSLDYYNSLMETVHLLRSPENAEHLNRSIAQYRAGQTTARD
LMDE

Nucleotide

• Length: 255 bp

>AT70651 NZ_CP018836:c645510-645256 [Vibrio gazogenes]
ATGAAAATTGTATCCTTTACGGAAGCGAGAAATAGTTTAAAAGCTGTTCTCGATGGTGTCGTGAATGATGCTGATACAAC
AGTAATTACTCGTCGTGATGCAGAGGATGCAGTCGTCATGTCCTTGGATTACTACAATAGCTTGATGGAAACCGTTCATT
TACTTCGTTCTCCAGAAAACGCAGAGCATCTAAATCGTTCGATTGCTCAATATCGTGCAGGTCAAACAACAGCTCGAGAT
TTAATGGATGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A1M4V2U4