Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 197977..198506 Replicon chromosome
Accession NZ_CP018828
Organism Enterococcus faecium strain ISMMS_VRE_12

Toxin (Protein)


Gene name relE Uniprot ID A0A828ZPW6
Locus tag AL026_RS02960 Protein ID WP_002301121.1
Coordinates 198240..198506 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag AL026_RS02955 Protein ID WP_002294199.1
Coordinates 197977..198240 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL026_RS02940 195352..197175 + 1824 WP_002294202.1 APC family permease -
AL026_RS02945 197317..197502 - 186 WP_002348885.1 hypothetical protein -
AL026_RS02955 197977..198240 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL026_RS02960 198240..198506 + 267 WP_002301121.1 Txe/YoeB family addiction module toxin Toxin
AL026_RS17225 198707..199541 + 835 Protein_195 hypothetical protein -
AL026_RS02975 199737..200408 - 672 WP_002301116.1 ABC transporter permease -
AL026_RS02980 200405..201322 - 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
AL026_RS02985 201319..201960 - 642 WP_002293405.1 ABC transporter permease -
AL026_RS02990 201964..203139 - 1176 WP_002348889.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - lap 92764..222641 129877


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10619.04 Da        Isoelectric Point: 9.8346

>T70643 WP_002301121.1 NZ_CP018828:198240-198506 [Enterococcus faecium]
MSNYTVAIKNSATVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T70643 NZ_CP018828:198240-198506 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGACAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAGAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT70643 WP_002294199.1 NZ_CP018828:197977-198240 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT70643 NZ_CP018828:197977-198240 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZPW6

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References