Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
Location | 197977..198506 | Replicon | chromosome |
Accession | NZ_CP018828 | ||
Organism | Enterococcus faecium strain ISMMS_VRE_12 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A828ZPW6 |
Locus tag | AL026_RS02960 | Protein ID | WP_002301121.1 |
Coordinates | 198240..198506 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | C9B8W8 |
Locus tag | AL026_RS02955 | Protein ID | WP_002294199.1 |
Coordinates | 197977..198240 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AL026_RS02940 | 195352..197175 | + | 1824 | WP_002294202.1 | APC family permease | - |
AL026_RS02945 | 197317..197502 | - | 186 | WP_002348885.1 | hypothetical protein | - |
AL026_RS02955 | 197977..198240 | + | 264 | WP_002294199.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
AL026_RS02960 | 198240..198506 | + | 267 | WP_002301121.1 | Txe/YoeB family addiction module toxin | Toxin |
AL026_RS17225 | 198707..199541 | + | 835 | Protein_195 | hypothetical protein | - |
AL026_RS02975 | 199737..200408 | - | 672 | WP_002301116.1 | ABC transporter permease | - |
AL026_RS02980 | 200405..201322 | - | 918 | WP_002301114.1 | osmoprotectant ABC transporter substrate-binding protein | - |
AL026_RS02985 | 201319..201960 | - | 642 | WP_002293405.1 | ABC transporter permease | - |
AL026_RS02990 | 201964..203139 | - | 1176 | WP_002348889.1 | betaine/proline/choline family ABC transporter ATP-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | lap | 92764..222641 | 129877 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10619.04 Da Isoelectric Point: 9.8346
>T70643 WP_002301121.1 NZ_CP018828:198240-198506 [Enterococcus faecium]
MSNYTVAIKNSATVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
MSNYTVAIKNSATVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
Download Length: 267 bp
>T70643 NZ_CP018828:198240-198506 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGACAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAGAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGACAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAGAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10016.03 Da Isoelectric Point: 4.1207
>AT70643 WP_002294199.1 NZ_CP018828:197977-198240 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL
Download Length: 264 bp
>AT70643 NZ_CP018828:197977-198240 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZPW6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZU84 |