70637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 692059..692677 Replicon chromosome
Accession NZ_CP018823
Organism Helicobacter pylori PMSS1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HPYLPMSS1_RS03450 Protein ID WP_077232042.1
Coordinates 692417..692677 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HPYLPMSS1_RS03445 Protein ID WP_077232041.1
Coordinates 692059..692430 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPYLPMSS1_RS03415 687768..688415 - 648 Protein_641 hypothetical protein -
HPYLPMSS1_RS03435 689131..691293 + 2163 WP_077232040.1 outer membrane beta-barrel protein -
HPYLPMSS1_RS03445 692059..692430 + 372 WP_077232041.1 hypothetical protein Antitoxin
HPYLPMSS1_RS03450 692417..692677 + 261 WP_077232042.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPYLPMSS1_RS03455 692755..693045 + 291 WP_077232043.1 hypothetical protein -
HPYLPMSS1_RS03460 693059..693220 + 162 WP_077232044.1 type II toxin-antitoxin system YafQ family toxin -
HPYLPMSS1_RS08050 693217..693416 + 200 Protein_647 virulence protein -
HPYLPMSS1_RS03470 693598..694122 - 525 WP_001135623.1 acyl-CoA thioesterase -
HPYLPMSS1_RS03475 694262..695116 + 855 WP_103153302.1 SDR family oxidoreductase -
HPYLPMSS1_RS03480 695109..696089 + 981 WP_077232045.1 iron ABC transporter permease -
HPYLPMSS1_RS03485 696089..696856 + 768 WP_000242355.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10250.18 Da        Isoelectric Point: 9.9512

>T70637 WP_077232042.1 NZ_CP018823:692417-692677 [Helicobacter pylori PMSS1]
MLKIRHHILFKKDFKKLVKNGFDDSVLNEVILRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILLRLG
SHSELF

Download         Length: 261 bp

>T70637 NZ_CP018823:692417-692677 [Helicobacter pylori PMSS1]
ATGCTGAAAATTAGGCACCATATCCTTTTCAAAAAAGACTTTAAAAAACTCGTTAAAAACGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAAGAAAAAAAGAACCGCTAGATCCACAATTTCAAGATCATGCCTTAAAGGGAAAGTGGAAACCTT
TTAGGGAATGCCACATCAAAGCCGACATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGGTTAGGC
AGTCATAGCGAGTTGTTTTAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14579.46 Da        Isoelectric Point: 5.3496

>AT70637 WP_077232041.1 NZ_CP018823:692059-692430 [Helicobacter pylori PMSS1]
MPNTTAEKDYTKYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHEIPNIQTQQAMRDALKDENLETIEDFSAWANEIKKEVNAEN

Download         Length: 372 bp

>AT70637 NZ_CP018823:692059-692430 [Helicobacter pylori PMSS1]
ATGCCTAACACCACCGCAGAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCATGAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGTTAAAAGACGAAAACTTAGAAACTATTGAAGA
CTTTTCTGCATGGGCAAATGAAATCAAAAAGGAAGTGAATGCTGAAAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References