Detailed information of TA system TA070636

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/DinJ(antitoxin)
• Location: 1838080..1838686
• Replicon: chromosome
• Accession: NZ_CP018822
• Organism: Streptococcus gallolyticus subsp. gallolyticus DSM 16831

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BTR42_RS09115
• Protein ID: WP_077497399.1
• Coordinates: 1838080..1838412 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1S5WDU6
• Locus tag: BTR42_RS09120
• Protein ID: WP_009854657.1
• Coordinates: 1838402..1838686 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR42_RS09090	1833511..1834119	-	609	WP_009854651.1	TVP38/TMEM64 family protein	-
BTR42_RS09095	1834367..1834669	-	303	WP_009854652.1	PepSY domain-containing protein	-
BTR42_RS09100	1834912..1836417	-	1506	WP_174564820.1	HAMP domain-containing histidine kinase	-
BTR42_RS09105	1836389..1837081	-	693	WP_009854654.1	response regulator transcription factor	-
BTR42_RS09110	1837187..1838065	-	879	WP_077497397.1	DUF3114 domain-containing protein	-
BTR42_RS09115	1838080..1838412	-	333	WP_077497399.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
BTR42_RS09120	1838402..1838686	-	285	WP_009854657.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BTR42_RS09125	1838960..1839478	+	519	WP_077497401.1	TetR/AcrR family transcriptional regulator	-
BTR42_RS09130	1839592..1841361	+	1770	WP_009854659.1	oleate hydratase	-
BTR42_RS09135	1841491..1842318	-	828	WP_077497403.1	class C sortase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (8-55)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12975.92 Da
• Isoelectric Point: 8.6852

>T70636 WP_077497399.1 NZ_CP018822:c1838412-1838080 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MDYKKYKLIYSQRGIDTLDDIYHYIANEIGSTINAKKKIASIRKDLQRLEFFPEGGFDADEKFGKCLDPKYKTRGLTLSK
DYIALYNILENEVRIAYLLPTRSDYMDLFR

Nucleotide

• Length: 333 bp

>T70636 NZ_CP018822:c1838412-1838080 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGGATTATAAGAAGTACAAGCTTATCTATTCTCAAAGGGGCATTGACACGCTTGATGATATTTATCATTATATTGCTAA
TGAAATAGGCTCAACAATTAACGCTAAAAAGAAAATTGCAAGTATTAGGAAAGATTTACAACGCTTGGAGTTTTTTCCAG
AGGGTGGTTTTGATGCTGATGAAAAATTTGGAAAGTGTCTGGATCCCAAGTATAAAACAAGAGGTTTAACGTTGAGTAAG
GACTATATTGCCTTGTATAACATTTTGGAAAATGAGGTTCGTATAGCATATTTGTTACCTACTCGCAGTGACTATATGGA
TTTATTTAGATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11125.47 Da
• Isoelectric Point: 4.7049

>AT70636 WP_009854657.1 NZ_CP018822:c1838686-1838402 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MALAYDKSYNLRTYQKIYNQAEKVFKENNLNTAQALNLFLKNVAETGQLNLKTEEELKREKLFKNLQAEIQQSYAEFDEG
KFYTDEDLVERYGL

Nucleotide

• Length: 285 bp

>AT70636 NZ_CP018822:c1838686-1838402 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGGCTTTAGCTTATGATAAAAGTTACAATTTAAGAACTTATCAAAAAATTTATAACCAAGCAGAAAAAGTATTTAAGGA
AAATAATTTAAATACCGCTCAGGCTTTAAATTTATTTCTAAAAAATGTTGCTGAAACAGGTCAACTTAATTTGAAAACAG
AAGAAGAACTTAAAAGAGAAAAGTTGTTTAAAAATCTTCAAGCAGAGATTCAACAAAGTTATGCTGAATTTGATGAAGGG
AAATTTTATACTGATGAGGATTTGGTAGAACGCTATGGATTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1S5WDU6