Detailed information of TA system TA070635

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 1661837..1662417
• Replicon: chromosome
• Accession: NZ_CP018822
• Organism: Streptococcus gallolyticus subsp. gallolyticus DSM 16831

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: F5WVJ0
• Locus tag: BTR42_RS08325
• Protein ID: WP_009854536.1
• Coordinates: 1662229..1662417 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BTR42_RS08320
• Protein ID: WP_077497294.1
• Coordinates: 1661837..1662217 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR42_RS08305	1657365..1657841	-	477	WP_014294902.1	shikimate kinase	-
BTR42_RS08310	1657834..1659117	-	1284	WP_077497290.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
BTR42_RS08315	1659339..1661174	-	1836	WP_077497292.1	translation elongation factor 4	-
BTR42_RS08320	1661837..1662217	-	381	WP_077497294.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BTR42_RS08325	1662229..1662417	-	189	WP_009854536.1	type II toxin-antitoxin system HicA family toxin	Toxin
BTR42_RS08330	1662513..1663178	-	666	WP_174564805.1	type II-A CRISPR-associated protein Csn2	-
BTR42_RS08335	1663165..1663509	-	345	WP_009854538.1	CRISPR-associated endonuclease Cas2	-
BTR42_RS08340	1663506..1664372	-	867	WP_077497298.1	type II CRISPR-associated endonuclease Cas1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6837.25 Da
• Isoelectric Point: 10.8207

>T70635 WP_009854536.1 NZ_CP018822:c1662417-1662229 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
VPLTGRELAKLAVLKGWKEVRVKGSHHQFKKDGVPYILTIPIHGNKVLGVGLEKKILKDIGL

Nucleotide

• Length: 189 bp

>T70635 NZ_CP018822:c1662417-1662229 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
GTGCCGCTAACAGGCAGAGAGTTAGCAAAACTTGCTGTGTTAAAAGGTTGGAAAGAAGTTCGTGTAAAGGGAAGTCATCA
TCAGTTCAAAAAGGATGGCGTACCCTATATTCTTACGATTCCAATTCATGGCAACAAGGTGTTAGGTGTAGGTTTGGAAA
AGAAAATTTTAAAAGACATAGGGCTATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14165.04 Da
• Isoelectric Point: 4.2627

>AT70635 WP_077497294.1 NZ_CP018822:c1662217-1661837 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MLKSYPAIFHKEDDGSFWVEFPGFGGGTEGDDVEEAMKNAREMLESSLAAYLDEGLELPKVVDMSELSVEDGFITLIQAD
PSPYLKSTKAIRKNVTVPEWLVRLADREHVNYSEVLTQALEKKLQL

Nucleotide

• Length: 381 bp

>AT70635 NZ_CP018822:c1662217-1661837 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGTTAAAATCATATCCAGCAATTTTTCACAAAGAAGATGATGGAAGTTTTTGGGTAGAATTTCCAGGATTTGGTGGTGG
TACCGAAGGTGATGATGTCGAAGAAGCGATGAAAAATGCTCGAGAAATGTTAGAAAGCTCATTGGCTGCTTATTTAGATG
AAGGGTTAGAGCTTCCAAAAGTTGTTGATATGAGTGAATTATCAGTTGAAGATGGTTTTATTACTTTAATTCAAGCAGAC
CCTTCCCCATATTTAAAAAGTACCAAAGCCATTCGAAAAAACGTTACGGTTCCAGAATGGTTAGTCAGATTAGCTGATAG
GGAACATGTTAATTATTCAGAAGTTTTGACACAAGCTTTAGAGAAAAAATTACAGCTTTAA

Structures

Toxin

• AlphaFold DB: A0A1S5WDX8