Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/YoeB-RelB |
Location | 1183908..1184424 | Replicon | chromosome |
Accession | NZ_CP018822 | ||
Organism | Streptococcus gallolyticus subsp. gallolyticus DSM 16831 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | F5X0X3 |
Locus tag | BTR42_RS06000 | Protein ID | WP_014620143.1 |
Coordinates | 1183908..1184165 (-) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | F5X0X4 |
Locus tag | BTR42_RS06005 | Protein ID | WP_012961966.1 |
Coordinates | 1184158..1184424 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BTR42_RS05975 | 1179393..1180001 | + | 609 | WP_077496832.1 | TipC family immunity protein | - |
BTR42_RS05980 | 1180184..1181032 | - | 849 | WP_077496834.1 | MurR/RpiR family transcriptional regulator | - |
BTR42_RS05985 | 1181202..1182185 | + | 984 | WP_077496836.1 | Gfo/Idh/MocA family oxidoreductase | - |
BTR42_RS05990 | 1182190..1182714 | + | 525 | WP_009854177.1 | heme-binding protein | - |
BTR42_RS05995 | 1182735..1183793 | + | 1059 | WP_077496838.1 | Gfo/Idh/MocA family oxidoreductase | - |
BTR42_RS06000 | 1183908..1184165 | - | 258 | WP_014620143.1 | Txe/YoeB family addiction module toxin | Toxin |
BTR42_RS06005 | 1184158..1184424 | - | 267 | WP_012961966.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
BTR42_RS06010 | 1184588..1184920 | + | 333 | WP_009854181.1 | putative DNA-binding protein | - |
BTR42_RS06015 | 1184991..1186556 | + | 1566 | WP_061100435.1 | signal recognition particle protein | - |
BTR42_RS06020 | 1186630..1187646 | - | 1017 | WP_077496840.1 | AraC family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10277.64 Da Isoelectric Point: 8.7825
>T70634 WP_014620143.1 NZ_CP018822:c1184165-1183908 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MIKAWSDDAWNDYMYWYNQGNKATIKKINRLIKEIDRTPFTGIGKPEPLKHDLSGKWSRRITDEHRLIYSVDETTIYFYS
CKDHY
MIKAWSDDAWNDYMYWYNQGNKATIKKINRLIKEIDRTPFTGIGKPEPLKHDLSGKWSRRITDEHRLIYSVDETTIYFYS
CKDHY
Download Length: 258 bp
>T70634 NZ_CP018822:c1184165-1183908 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGATTAAAGCATGGTCTGACGATGCGTGGAACGACTATATGTATTGGTATAATCAAGGAAATAAAGCGACAATTAAAAA
AATTAATCGCCTAATCAAGGAGATTGACCGCACTCCTTTTACTGGCATTGGTAAACCTGAACCACTTAAACACGATTTAT
CTGGCAAATGGTCACGACGCATAACCGATGAACATCGTTTAATTTACAGTGTTGATGAAACTACTATTTACTTTTATTCT
TGCAAAGACCATTATTAA
ATGATTAAAGCATGGTCTGACGATGCGTGGAACGACTATATGTATTGGTATAATCAAGGAAATAAAGCGACAATTAAAAA
AATTAATCGCCTAATCAAGGAGATTGACCGCACTCCTTTTACTGGCATTGGTAAACCTGAACCACTTAAACACGATTTAT
CTGGCAAATGGTCACGACGCATAACCGATGAACATCGTTTAATTTACAGTGTTGATGAAACTACTATTTACTTTTATTCT
TGCAAAGACCATTATTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10365.60 Da Isoelectric Point: 4.6290
>AT70634 WP_012961966.1 NZ_CP018822:c1184424-1184158 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MEAVAYSNFRQNLKHYMKQVNDDAEPLIVTSKNIDDTVVVLSKRDYDSMQETFRIMSNNYLMNKIKRGDEQFKAANFQTH
ELLEVDDD
MEAVAYSNFRQNLKHYMKQVNDDAEPLIVTSKNIDDTVVVLSKRDYDSMQETFRIMSNNYLMNKIKRGDEQFKAANFQTH
ELLEVDDD
Download Length: 267 bp
>AT70634 NZ_CP018822:c1184424-1184158 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGGAAGCTGTTGCATATTCAAATTTTAGACAAAATTTAAAACATTATATGAAACAAGTTAATGATGACGCTGAACCACT
TATTGTAACTTCTAAAAATATTGATGACACTGTCGTAGTCCTTTCAAAACGTGACTATGATAGCATGCAAGAAACATTTC
GCATTATGTCTAATAACTACCTAATGAATAAAATTAAACGCGGCGATGAACAATTCAAAGCAGCTAATTTTCAGACACAT
GAATTGCTCGAGGTAGATGATGATTAA
ATGGAAGCTGTTGCATATTCAAATTTTAGACAAAATTTAAAACATTATATGAAACAAGTTAATGATGACGCTGAACCACT
TATTGTAACTTCTAAAAATATTGATGACACTGTCGTAGTCCTTTCAAAACGTGACTATGATAGCATGCAAGAAACATTTC
GCATTATGTCTAATAACTACCTAATGAATAAAATTAAACGCGGCGATGAACAATTCAAAGCAGCTAATTTTCAGACACAT
GAATTGCTCGAGGTAGATGATGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1S5WCL9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1S5WCN9 |