Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/YoeB-RelB
Location 1183908..1184424 Replicon chromosome
Accession NZ_CP018822
Organism Streptococcus gallolyticus subsp. gallolyticus DSM 16831

Toxin (Protein)


Gene name Txe Uniprot ID F5X0X3
Locus tag BTR42_RS06000 Protein ID WP_014620143.1
Coordinates 1183908..1184165 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID F5X0X4
Locus tag BTR42_RS06005 Protein ID WP_012961966.1
Coordinates 1184158..1184424 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTR42_RS05975 1179393..1180001 + 609 WP_077496832.1 TipC family immunity protein -
BTR42_RS05980 1180184..1181032 - 849 WP_077496834.1 MurR/RpiR family transcriptional regulator -
BTR42_RS05985 1181202..1182185 + 984 WP_077496836.1 Gfo/Idh/MocA family oxidoreductase -
BTR42_RS05990 1182190..1182714 + 525 WP_009854177.1 heme-binding protein -
BTR42_RS05995 1182735..1183793 + 1059 WP_077496838.1 Gfo/Idh/MocA family oxidoreductase -
BTR42_RS06000 1183908..1184165 - 258 WP_014620143.1 Txe/YoeB family addiction module toxin Toxin
BTR42_RS06005 1184158..1184424 - 267 WP_012961966.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BTR42_RS06010 1184588..1184920 + 333 WP_009854181.1 putative DNA-binding protein -
BTR42_RS06015 1184991..1186556 + 1566 WP_061100435.1 signal recognition particle protein -
BTR42_RS06020 1186630..1187646 - 1017 WP_077496840.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10277.64 Da        Isoelectric Point: 8.7825

>T70634 WP_014620143.1 NZ_CP018822:c1184165-1183908 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MIKAWSDDAWNDYMYWYNQGNKATIKKINRLIKEIDRTPFTGIGKPEPLKHDLSGKWSRRITDEHRLIYSVDETTIYFYS
CKDHY

Download         Length: 258 bp

>T70634 NZ_CP018822:c1184165-1183908 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGATTAAAGCATGGTCTGACGATGCGTGGAACGACTATATGTATTGGTATAATCAAGGAAATAAAGCGACAATTAAAAA
AATTAATCGCCTAATCAAGGAGATTGACCGCACTCCTTTTACTGGCATTGGTAAACCTGAACCACTTAAACACGATTTAT
CTGGCAAATGGTCACGACGCATAACCGATGAACATCGTTTAATTTACAGTGTTGATGAAACTACTATTTACTTTTATTCT
TGCAAAGACCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10365.60 Da        Isoelectric Point: 4.6290

>AT70634 WP_012961966.1 NZ_CP018822:c1184424-1184158 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MEAVAYSNFRQNLKHYMKQVNDDAEPLIVTSKNIDDTVVVLSKRDYDSMQETFRIMSNNYLMNKIKRGDEQFKAANFQTH
ELLEVDDD

Download         Length: 267 bp

>AT70634 NZ_CP018822:c1184424-1184158 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGGAAGCTGTTGCATATTCAAATTTTAGACAAAATTTAAAACATTATATGAAACAAGTTAATGATGACGCTGAACCACT
TATTGTAACTTCTAAAAATATTGATGACACTGTCGTAGTCCTTTCAAAACGTGACTATGATAGCATGCAAGAAACATTTC
GCATTATGTCTAATAACTACCTAATGAATAAAATTAAACGCGGCGATGAACAATTCAAAGCAGCTAATTTTCAGACACAT
GAATTGCTCGAGGTAGATGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S5WCL9

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WCN9

References