Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 710618..711104 Replicon chromosome
Accession NZ_CP018822
Organism Streptococcus gallolyticus subsp. gallolyticus DSM 16831

Toxin (Protein)


Gene name relE Uniprot ID A0A1S5WAV3
Locus tag BTR42_RS03850 Protein ID WP_009853752.1
Coordinates 710835..711104 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F5WZP8
Locus tag BTR42_RS03845 Protein ID WP_013642845.1
Coordinates 710618..710845 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTR42_RS03825 706755..707069 + 315 WP_003063779.1 metalloregulator ArsR/SmtB family transcription factor -
BTR42_RS03830 707072..708955 + 1884 WP_077496480.1 cadmium-translocating P-type ATPase -
BTR42_RS03835 709115..709435 + 321 WP_077496482.1 multidrug efflux SMR transporter -
BTR42_RS03840 709652..710344 + 693 WP_009853732.1 phosphoglycerate mutase -
BTR42_RS03845 710618..710845 + 228 WP_013642845.1 hypothetical protein Antitoxin
BTR42_RS03850 710835..711104 + 270 WP_009853752.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTR42_RS03855 711483..712049 - 567 WP_009853753.1 DUF3267 domain-containing protein -
BTR42_RS03860 712300..712821 + 522 WP_009853754.1 transcription repressor NadR -
BTR42_RS03865 713018..713572 + 555 WP_043878534.1 hypothetical protein -
BTR42_RS03870 713727..715880 + 2154 WP_009853756.1 penicillin-binding protein PBP2B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10554.64 Da        Isoelectric Point: 10.4700

>T70633 WP_009853752.1 NZ_CP018822:710835-711104 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MTYRLVVSDKVKKQLKKMDKHVRLMLAKDMKKHLDGLENPRQIGKALIGQFKGLWRYRIGNYRVICDIMDDELVILAIEI
GHRKDIYKN

Download         Length: 270 bp

>T70633 NZ_CP018822:710835-711104 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGACTTATAGATTGGTTGTTAGTGACAAGGTCAAGAAACAACTAAAGAAAATGGATAAGCATGTAAGGCTTATGCTTGC
TAAAGACATGAAGAAACACCTTGATGGTTTAGAGAACCCTAGACAAATTGGAAAAGCACTAATAGGTCAATTCAAAGGCC
TATGGCGTTACCGAATAGGAAATTATAGAGTTATTTGTGATATTATGGACGATGAATTAGTTATTCTTGCTATTGAAATC
GGACATAGAAAAGATATTTATAAAAACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8732.81 Da        Isoelectric Point: 4.3239

>AT70633 WP_013642845.1 NZ_CP018822:710618-710845 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MSIVSLRLNEKEEELFRSYSIHTGKTLSELFKTALAEQIEDQLDYETGIKALKEFKKNPVTHSIDDIIEEFENDL

Download         Length: 228 bp

>AT70633 NZ_CP018822:710618-710845 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGTCAATCGTATCACTTAGACTAAATGAAAAAGAAGAAGAACTTTTTAGAAGTTATTCTATCCATACAGGAAAGACATT
ATCAGAGTTGTTTAAAACAGCTTTAGCTGAACAAATTGAAGACCAATTAGATTATGAAACAGGCATTAAAGCATTGAAAG
AATTCAAAAAGAATCCTGTTACTCACTCTATTGATGATATTATTGAGGAGTTTGAAAATGACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S5WAV3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WAU8

References