Detailed information of TA system TA070632

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 277100..277651
• Replicon: chromosome
• Accession: NZ_CP018822
• Organism: Streptococcus gallolyticus subsp. gallolyticus DSM 16831

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BTR42_RS01610
• Protein ID: WP_077496088.1
• Coordinates: 277100..277378 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BTR42_RS01615
• Protein ID: WP_077496090.1
• Coordinates: 277379..277651 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR42_RS01575	273208..273462	-	255	WP_049533167.1	Txe/YoeB family addiction module toxin	-
BTR42_RS01580	273455..273721	-	267	WP_077496080.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
BTR42_RS01585	273984..275642	-	1659	WP_077496082.1	cell division protein FtsK	-
BTR42_RS01590	275649..276059	-	411	WP_003041912.1	DUF961 family protein	-
BTR42_RS01595	276082..276396	-	315	WP_000406626.1	hypothetical protein	-
BTR42_RS01600	276511..276738	-	228	WP_077496084.1	TetR family transcriptional regulator	-
BTR42_RS01605	276735..276971	-	237	WP_077496086.1	hypothetical protein	-
BTR42_RS01610	277100..277378	-	279	WP_077496088.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BTR42_RS01615	277379..277651	-	273	WP_077496090.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BTR42_RS01620	278325..278687	+	363	WP_049533221.1	helix-turn-helix domain-containing protein	-
BTR42_RS01625	278694..279545	+	852	WP_174564796.1	ImmA/IrrE family metallo-endopeptidase	-
BTR42_RS01630	279565..279918	-	354	WP_077496092.1	hypothetical protein	-
BTR42_RS01635	280228..280698	+	471	WP_077497992.1	hypothetical protein	-
BTR42_RS01640	280725..280967	+	243	Protein_273	hypothetical protein	-
BTR42_RS01645	280986..281467	-	482	Protein_274	IS982 family transposase	-
BTR42_RS01650	281955..282149	+	195	WP_077496094.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	220747..290158	69411

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-81)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10908.78 Da
• Isoelectric Point: 8.0384

>T70632 WP_077496088.1 NZ_CP018822:c277378-277100 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MYQVKFTSAFKKSYKRIKKRGLEMALLDEVIEKLRLGQTLEEKYRDHELKGNFVGFRECHIKPDWLLIYLIEEDILTLTL
ADTGSHADLFKM

Nucleotide

• Length: 279 bp

>T70632 NZ_CP018822:c277378-277100 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGTACCAAGTTAAGTTTACCTCTGCTTTTAAAAAGAGCTATAAACGAATTAAAAAGCGAGGCTTAGAGATGGCACTCTT
AGATGAAGTGATTGAAAAACTTCGTTTAGGTCAGACACTAGAAGAAAAATACCGTGACCATGAACTCAAAGGAAACTTTG
TTGGCTTTAGGGAATGTCATATTAAACCAGATTGGCTTTTGATTTATCTGATTGAAGAGGATATTTTGACCCTAACGTTA
GCCGATACAGGCAGTCATGCGGATTTGTTTAAGATGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9891.32 Da
• Isoelectric Point: 4.7085

>AT70632 WP_077496090.1 NZ_CP018822:c277651-277379 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MATVPTQIRIDETVKAQATSLFNDLGMDMSSAVNIFLRQCLLRGGLPFTVEVPNYSQKTLEALAEAKRISRDETVASYDN
LADLKKALDA

Nucleotide

• Length: 273 bp

>AT70632 NZ_CP018822:c277651-277379 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGGCAACTGTACCAACTCAAATTCGGATTGATGAAACTGTAAAAGCCCAAGCAACTTCATTATTTAATGACTTGGGGAT
GGATATGTCTAGTGCAGTCAATATTTTTCTTCGTCAATGTCTATTGCGTGGTGGACTTCCTTTCACGGTTGAAGTCCCCA
ATTATAGTCAAAAGACCTTAGAAGCTCTGGCAGAAGCTAAGCGTATTTCTCGTGATGAAACGGTCGCTTCTTATGACAAT
CTAGCAGATTTAAAGAAGGCTCTGGACGCTTAG