Detailed information of TA system TA070630

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 259739..260348
• Replicon: chromosome
• Accession: NZ_CP018822
• Organism: Streptococcus gallolyticus subsp. gallolyticus DSM 16831

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BTR42_RS01490
• Protein ID: WP_077496054.1
• Coordinates: 259739..260068 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1S5WA73
• Locus tag: BTR42_RS01495
• Protein ID: WP_013642908.1
• Coordinates: 260058..260348 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR42_RS01465	254838..255491	+	654	WP_077496047.1	hypothetical protein	-
BTR42_RS12745	255554..256426	+	873	WP_174564795.1	DnaD domain protein	-
BTR42_RS01475	256792..257286	+	495	WP_077496049.1	hypothetical protein	-
BTR42_RS01480	257601..258857	+	1257	WP_077496051.1	plasmid recombination protein	-
BTR42_RS01485	259030..259560	+	531	WP_077496052.1	hypothetical protein	-
BTR42_RS01490	259739..260068	-	330	WP_077496054.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTR42_RS01495	260058..260348	-	291	WP_013642908.1	hypothetical protein	Antitoxin
BTR42_RS01500	260748..261971	-	1224	WP_077496056.1	site-specific integrase	-
BTR42_RS01505	262026..262299	-	274	Protein_246	helix-turn-helix domain-containing protein	-
BTR42_RS01510	262411..262743	-	333	WP_077496058.1	type II toxin-antitoxin system PemK/MazF family toxin	-
BTR42_RS01515	262730..263035	-	306	WP_000162871.1	hypothetical protein	-
BTR42_RS01520	263092..264147	-	1056	WP_077496059.1	CHAP domain-containing protein	-
BTR42_RS01525	264156..264383	-	228	WP_077496061.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	220747..290158	69411

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12555.47 Da
• Isoelectric Point: 8.3467

>T70630 WP_077496054.1 NZ_CP018822:c260068-259739 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MDYKISYNAGALEALVEIKEYIINNFKSETSAKKVVDNIMQKISALEIFPEVGFDADERFGKTLDKRHKTRGLTIGKDYI
ALYFVNDEKKEVVITHIVSTRSDYVKLFK

Nucleotide

• Length: 330 bp

>T70630 NZ_CP018822:c260068-259739 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
TTGGATTATAAAATAAGTTATAACGCTGGTGCTTTGGAAGCATTGGTAGAAATAAAAGAATATATAATTAATAATTTCAA
GTCAGAAACATCAGCGAAAAAGGTAGTTGATAATATCATGCAAAAAATAAGTGCTTTAGAGATTTTTCCTGAAGTAGGGT
TTGATGCTGATGAAAGATTTGGAAAAACTTTAGATAAGCGTCATAAAACTAGAGGTTTAACAATCGGGAAAGATTATATA
GCTTTATATTTTGTTAATGATGAAAAAAAGGAAGTTGTCATTACCCATATTGTCTCAACTCGAAGTGATTATGTGAAATT
GTTCAAATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11015.58 Da
• Isoelectric Point: 4.9477

>AT70630 WP_013642908.1 NZ_CP018822:c260348-260058 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
MVVAEKNRAVTFQANKELVSEAKEVLNKKNLTLSHALRLFLQNVVVTNEIDLLNEEELEKEKLFRQLQGEIKQAIDDYEA
GVNTYSAEEVRKRLGL

Nucleotide

• Length: 291 bp

>AT70630 NZ_CP018822:c260348-260058 [Streptococcus gallolyticus subsp. gallolyticus DSM 16831]
ATGGTAGTTGCAGAAAAAAATAGAGCCGTCACTTTTCAAGCTAATAAAGAATTAGTAAGCGAAGCTAAAGAAGTTTTAAA
TAAAAAGAATTTGACATTATCACATGCTTTAAGATTATTTTTACAAAATGTTGTTGTTACTAATGAAATTGACTTGTTGA
ACGAAGAAGAGCTAGAAAAAGAGAAGTTATTTAGACAACTTCAAGGAGAAATAAAGCAAGCTATAGATGATTATGAAGCT
GGTGTAAATACTTATTCAGCTGAAGAGGTGAGAAAACGTCTTGGATTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1S5WA73