Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1627816..1628473 Replicon chromosome
Accession NZ_CP018816
Organism Klebsiella pneumoniae strain AR_0049

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AM428_RS08635 Protein ID WP_002916310.1
Coordinates 1628063..1628473 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AM428_RS08630 Protein ID WP_002916312.1
Coordinates 1627816..1628082 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM428_RS08605 1622972..1624405 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
AM428_RS08610 1624524..1625252 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
AM428_RS08615 1625302..1625613 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
AM428_RS08620 1625777..1626436 + 660 WP_002916317.1 hemolysin III family protein -
AM428_RS08625 1626587..1627570 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
AM428_RS08630 1627816..1628082 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AM428_RS08635 1628063..1628473 + 411 WP_002916310.1 protein YgfX Toxin
AM428_RS08640 1628480..1629001 - 522 WP_002916308.1 flavodoxin FldB -
AM428_RS08645 1629102..1629998 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AM428_RS08650 1630021..1630734 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM428_RS08655 1630740..1632473 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T70615 WP_002916310.1 NZ_CP018816:1628063-1628473 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T70615 NZ_CP018816:1628063-1628473 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT70615 WP_002916312.1 NZ_CP018816:1627816-1628082 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT70615 NZ_CP018816:1627816-1628082 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References