Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4610557..4611214 Replicon chromosome
Accession NZ_CP018814
Organism Enterobacter cloacae complex sp. AR_0002

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag AM329_RS22930 Protein ID WP_022649305.1
Coordinates 4610804..4611214 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag AM329_RS22925 Protein ID WP_003863437.1
Coordinates 4610557..4610823 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM329_RS22900 (AM329_22150) 4605989..4607422 - 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -
AM329_RS22905 (AM329_22155) 4607539..4608270 - 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
AM329_RS22915 (AM329_22165) 4608537..4609196 + 660 WP_003863433.1 hemolysin III family protein -
AM329_RS22920 (AM329_22170) 4609282..4610262 - 981 WP_022649306.1 tRNA-modifying protein YgfZ -
AM329_RS22925 (AM329_22175) 4610557..4610823 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
AM329_RS22930 (AM329_22180) 4610804..4611214 + 411 WP_022649305.1 protein YgfX Toxin
AM329_RS22935 (AM329_22185) 4611216..4611737 - 522 WP_003863440.1 flavodoxin FldB -
AM329_RS22940 (AM329_22190) 4611839..4612735 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
AM329_RS22945 (AM329_22195) 4612764..4613477 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM329_RS22950 (AM329_22200) 4613483..4615216 + 1734 WP_032610082.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T70605 WP_022649305.1 NZ_CP018814:4610804-4611214 [Enterobacter cloacae complex sp. AR_0002]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T70605 NZ_CP018814:4610804-4611214 [Enterobacter cloacae complex sp. AR_0002]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCAA
CGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT70605 WP_003863437.1 NZ_CP018814:4610557-4610823 [Enterobacter cloacae complex sp. AR_0002]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT70605 NZ_CP018814:4610557-4610823 [Enterobacter cloacae complex sp. AR_0002]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References