Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 2944427..2945106 | Replicon | chromosome |
| Accession | NZ_CP018814 | ||
| Organism | Enterobacter cloacae complex sp. AR_0002 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | AM329_RS14485 | Protein ID | WP_032608412.1 |
| Coordinates | 2944427..2944768 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | - |
| Locus tag | AM329_RS14490 | Protein ID | WP_020456353.1 |
| Coordinates | 2944789..2945106 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AM329_RS14450 (AM329_14040) | 2939920..2940171 | + | 252 | WP_032608418.1 | hypothetical protein | - |
| AM329_RS14455 (AM329_14045) | 2940244..2940468 | + | 225 | WP_032608417.1 | colicin E3-like toxin immunity protein | - |
| AM329_RS14460 (AM329_14050) | 2940527..2940775 | + | 249 | WP_032608415.1 | bacteriocin immunity protein | - |
| AM329_RS14465 (AM329_14055) | 2940890..2941261 | + | 372 | WP_032608414.1 | hypothetical protein | - |
| AM329_RS14470 | 2941341..2941814 | - | 474 | WP_072163380.1 | SymE family type I addiction module toxin | - |
| AM329_RS14475 (AM329_14065) | 2942115..2942984 | + | 870 | WP_032608413.1 | HNH endonuclease | - |
| AM329_RS14480 (AM329_14070) | 2943165..2944172 | - | 1008 | WP_020456355.1 | restriction endonuclease | - |
| AM329_RS14485 (AM329_14075) | 2944427..2944768 | - | 342 | WP_032608412.1 | TA system toxin CbtA family protein | Toxin |
| AM329_RS14490 (AM329_14080) | 2944789..2945106 | - | 318 | WP_020456353.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| AM329_RS14495 (AM329_14085) | 2945124..2945345 | - | 222 | WP_032608411.1 | DUF987 domain-containing protein | - |
| AM329_RS14500 (AM329_14090) | 2945354..2945833 | - | 480 | WP_020456351.1 | DNA repair protein RadC | - |
| AM329_RS14505 (AM329_14095) | 2945876..2946094 | - | 219 | WP_020456350.1 | hypothetical protein | - |
| AM329_RS14510 (AM329_14100) | 2946104..2946562 | - | 459 | WP_032608410.1 | antirestriction protein | - |
| AM329_RS25570 | 2946668..2946868 | - | 201 | WP_050596949.1 | DUF905 family protein | - |
| AM329_RS14520 (AM329_14105) | 2946996..2947862 | - | 867 | WP_032608409.1 | hypothetical protein | - |
| AM329_RS26255 | 2947926..2948048 | - | 123 | WP_020456347.1 | hypothetical protein | - |
| AM329_RS14525 (AM329_14110) | 2948101..2948784 | - | 684 | WP_020456346.1 | DeoR family transcriptional regulator | - |
| AM329_RS25240 (AM329_14115) | 2948993..2949817 | - | 825 | Protein_2801 | DUF945 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | fosA | - | 2924030..2977101 | 53071 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12747.73 Da Isoelectric Point: 9.0060
>T70602 WP_032608412.1 NZ_CP018814:c2944768-2944427 [Enterobacter cloacae complex sp. AR_0002]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
Download Length: 342 bp
>T70602 NZ_CP018814:c2944768-2944427 [Enterobacter cloacae complex sp. AR_0002]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11846.39 Da Isoelectric Point: 5.5403
>AT70602 WP_020456353.1 NZ_CP018814:c2945106-2944789 [Enterobacter cloacae complex sp. AR_0002]
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR
Download Length: 318 bp
>AT70602 NZ_CP018814:c2945106-2944789 [Enterobacter cloacae complex sp. AR_0002]
ATGAGCAACACCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTTCAGGAGGGCAACTGGCT
GCACTATTTGGCTGACCGAGCCAGTATTACCGGTAAATTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGTATTTCCGA
ATTTTATCAGCCAGTTGGAGTCAATGCTTACCACTGGTGAAATGAACCCTAGCCATGCCTATTGTGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCAACGTTAA
ATGAGCAACACCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTTCAGGAGGGCAACTGGCT
GCACTATTTGGCTGACCGAGCCAGTATTACCGGTAAATTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGTATTTCCGA
ATTTTATCAGCCAGTTGGAGTCAATGCTTACCACTGGTGAAATGAACCCTAGCCATGCCTATTGTGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCAACGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|