Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1248653..1249392 Replicon chromosome
Accession NZ_CP018814
Organism Enterobacter cloacae complex sp. AR_0002

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag AM329_RS06190 Protein ID WP_032609220.1
Coordinates 1248907..1249392 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag AM329_RS06185 Protein ID WP_003857131.1
Coordinates 1248653..1248919 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM329_RS06165 (AM329_05970) 1244129..1245115 + 987 WP_003857123.1 DUF979 domain-containing protein -
AM329_RS06170 (AM329_05975) 1245125..1246120 + 996 WP_023314163.1 DUF2891 domain-containing protein -
AM329_RS06175 (AM329_05980) 1246142..1247530 - 1389 WP_032609222.1 MFS transporter -
AM329_RS06180 (AM329_05985) 1247660..1248589 + 930 WP_032609221.1 LysR family transcriptional regulator -
AM329_RS06185 (AM329_05990) 1248653..1248919 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
AM329_RS06190 (AM329_05995) 1248907..1249392 + 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
AM329_RS06195 (AM329_06000) 1249586..1250989 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
AM329_RS06200 (AM329_06005) 1251018..1251650 - 633 WP_001567369.1 hypothetical protein -
AM329_RS06205 (AM329_06010) 1251725..1252096 + 372 Protein_1196 IS5/IS1182 family transposase -
AM329_RS06210 (AM329_06015) 1252128..1253096 + 969 WP_013815099.1 IS5-like element IS903B family transposase -
AM329_RS06215 (AM329_06020) 1253257..1254072 + 816 WP_012695470.1 aminoglycoside O-phosphotransferase APH(3')-Ia -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T70600 WP_032609220.1 NZ_CP018814:1248907-1249392 [Enterobacter cloacae complex sp. AR_0002]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T70600 NZ_CP018814:1248907-1249392 [Enterobacter cloacae complex sp. AR_0002]
GTGGGACGTGTAACAGCGCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTTGTCATTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCACTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGTAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATACTTGCCCGTCTGGCTGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCCTCGCAGACTCAGGAACGGACACTGTTTCTCCGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT70600 WP_003857131.1 NZ_CP018814:1248653-1248919 [Enterobacter cloacae complex sp. AR_0002]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT70600 NZ_CP018814:1248653-1248919 [Enterobacter cloacae complex sp. AR_0002]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACAGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References