Detailed information of TA system TA070588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 485287..485768
• Replicon: chromosome
• Accession: NZ_CP018808
• Organism: Histophilus somni strain USDA-ARS-USMARC-63374

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BTV21_RS02240
• Protein ID: WP_075294307.1
• Coordinates: 485287..485547 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BTV21_RS02245
• Protein ID: WP_075294306.1
• Coordinates: 485547..485768 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTV21_RS02215	481347..482687	+	1341	WP_075294311.1	PTS sugar transporter subunit IIC	-
BTV21_RS02220	482753..483172	+	420	WP_075294310.1	pseudouridine synthase	-
BTV21_RS02225	483351..483542	+	192	WP_075294309.1	hypothetical protein	-
BTV21_RS02230	483658..485109	+	1452	WP_075294308.1	DUF560 domain-containing protein	-
BTV21_RS02235	485173..485283	+	111	Protein_435	CAAX protease	-
BTV21_RS02240	485287..485547	-	261	WP_075294307.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTV21_RS02245	485547..485768	-	222	WP_075294306.1	CopG family transcriptional regulator	Antitoxin
BTV21_RS02250	486204..488124	+	1921	Protein_438	transferrin-binding protein-like solute binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	467511..496292	28781

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10029.68 Da
• Isoelectric Point: 9.9542

>T70588 WP_075294307.1 NZ_CP018808:c485547-485287 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTGNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T70588 NZ_CP018808:c485547-485287 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAACTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTGGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8543.65 Da
• Isoelectric Point: 4.4284

>AT70588 WP_075294306.1 NZ_CP018808:c485768-485547 [Histophilus somni]
MAISIRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEEYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT70588 NZ_CP018808:c485768-485547 [Histophilus somni]
ATGGCTATTTCAATAAGATTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGAAT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA