Detailed information of TA system TA070586

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1355893..1356492
• Replicon: chromosome
• Accession: NZ_CP018807
• Organism: Histophilus somni strain USDA-ARS-USMARC-63373

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UV74
• Locus tag: BTV22_RS05885
• Protein ID: WP_012340732.1
• Coordinates: 1355893..1356198 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BTV22_RS05890
• Protein ID: WP_075294500.1
• Coordinates: 1356202..1356492 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTV22_RS05865	1351243..1352103	+	861	WP_075294502.1	RNase adapter RapZ	-
BTV22_RS05870	1352139..1354190	-	2052	WP_075294501.1	methionine--tRNA ligase	-
BTV22_RS05875	1354331..1355452	+	1122	WP_012340731.1	iron-sulfur cluster carrier protein ApbC	-
BTV22_RS05880	1355436..1355672	-	237	WP_080514392.1	recombinase family protein	-
BTV22_RS05885	1355893..1356198	-	306	WP_012340732.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
BTV22_RS05890	1356202..1356492	-	291	WP_075294500.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BTV22_RS05895	1356664..1357227	-	564	WP_178384292.1	molecular chaperone	-
BTV22_RS05900	1357224..1357844	-	621	WP_011608731.1	NAD(P)H-dependent oxidoreductase	-
BTV22_RS05905	1357854..1358297	-	444	WP_012340735.1	NfeD family protein	-
BTV22_RS05910	1358344..1359264	-	921	WP_011608729.1	SPFH/Band 7/PHB domain protein	-
BTV22_RS05915	1359547..1359999	+	453	WP_011608728.1	type II 3-dehydroquinate dehydratase	-
BTV22_RS05920	1360188..1360649	+	462	WP_012340736.1	acetyl-CoA carboxylase biotin carboxyl carrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-97)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-93)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11745.47 Da
• Isoelectric Point: 8.9207

>T70586 WP_012340732.1 NZ_CP018807:c1356198-1355893 [Histophilus somni]
MSGKQLKVSYSKQFARDLTDLAKRYPNVLVGTKYITAMHCLLNRLPLPESYQDHTLVGEWKGYRDCHIQGDLVLIYQYVI
HDEFDALKFSRLNTYSQTASK

Nucleotide

• Length: 306 bp

>T70586 NZ_CP018807:c1356198-1355893 [Histophilus somni]
ATGTCTGGTAAACAATTAAAGGTCAGTTACTCTAAACAATTTGCTAGAGATTTGACTGATTTGGCAAAACGTTACCCAAA
TGTGCTAGTAGGAACGAAATATATTACAGCAATGCACTGCTTGTTAAACCGCTTGCCATTGCCTGAAAGCTATCAAGATC
ACACATTAGTTGGAGAATGGAAAGGTTATCGAGATTGCCATATTCAAGGGGATTTGGTGCTGATTTACCAATACGTTATA
CACGATGAATTTGATGCGTTGAAATTTTCTCGTTTAAATACCTACTCGCAAACAGCTTCAAAATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10832.18 Da
• Isoelectric Point: 4.2845

>AT70586 WP_075294500.1 NZ_CP018807:c1356492-1356202 [Histophilus somni]
MALTNASISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLVQIAKTRSIPVDLNYLRPNKETLAAMDELDSGNAESFFIEA
GENYSVEEFTKRILNG

Nucleotide

• Length: 291 bp

>AT70586 NZ_CP018807:c1356492-1356202 [Histophilus somni]
ATGGCACTTACAAATGCGTCTATCAGCTTTAGAACAGTTGAGCAAACTAAATCCGAAGCCTATCAGGTCATTGAACAATA
TGGTCTTACACCATCACAAGTATTTAATATGTTTTTGGTTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCTTAGCAGCTATGGACGAATTAGATAGCGGTAATGCAGAGAGCTTTTTTATTGAAGCT
GGAGAAAATTATTCTGTCGAAGAGTTTACAAAACGCATTCTTAACGGGTAA

Structures

Toxin

• AlphaFold DB: B0UV74