Detailed information of TA system TA070585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 481817..482298
• Replicon: chromosome
• Accession: NZ_CP018807
• Organism: Histophilus somni strain USDA-ARS-USMARC-63373

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BTV22_RS02220
• Protein ID: WP_075294307.1
• Coordinates: 481817..482077 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BTV22_RS02225
• Protein ID: WP_075294306.1
• Coordinates: 482077..482298 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTV22_RS02195	477877..479217	+	1341	WP_075294311.1	PTS sugar transporter subunit IIC	-
BTV22_RS02200	479283..479702	+	420	WP_075294310.1	pseudouridine synthase	-
BTV22_RS02205	479881..480072	+	192	WP_075294309.1	hypothetical protein	-
BTV22_RS02210	480188..481639	+	1452	WP_075294308.1	DUF560 domain-containing protein	-
BTV22_RS02215	481703..481813	+	111	Protein_429	CAAX protease	-
BTV22_RS02220	481817..482077	-	261	WP_075294307.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTV22_RS02225	482077..482298	-	222	WP_075294306.1	CopG family transcriptional regulator	Antitoxin
BTV22_RS02230	482734..484654	+	1921	Protein_432	transferrin-binding protein-like solute binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10029.68 Da
• Isoelectric Point: 9.9542

>T70585 WP_075294307.1 NZ_CP018807:c482077-481817 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTGNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T70585 NZ_CP018807:c482077-481817 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAACTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTGGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8543.65 Da
• Isoelectric Point: 4.4284

>AT70585 WP_075294306.1 NZ_CP018807:c482298-482077 [Histophilus somni]
MAISIRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEEYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT70585 NZ_CP018807:c482298-482077 [Histophilus somni]
ATGGCTATTTCAATAAGATTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGAAT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA