Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 460897..461629 Replicon chromosome
Accession NZ_CP018806
Organism Histophilus somni strain USDA-ARS-USMARC-63370

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag BTV17_RS02350 Protein ID WP_075294106.1
Coordinates 461162..461629 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag BTV17_RS02345 Protein ID WP_011609927.1
Coordinates 460897..461160 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTV17_RS02315 456005..456367 + 363 WP_135026582.1 hypothetical protein -
BTV17_RS02320 456430..458718 + 2289 WP_075321885.1 hypothetical protein -
BTV17_RS10070 459384..460040 + 657 WP_157665518.1 hypothetical protein -
BTV17_RS02335 460194..460448 + 255 WP_075294108.1 DUF1778 domain-containing protein -
BTV17_RS02340 460448..460759 + 312 WP_075294107.1 hypothetical protein -
BTV17_RS02345 460897..461160 + 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
BTV17_RS02350 461162..461629 + 468 WP_075294106.1 GNAT family N-acetyltransferase Toxin
BTV17_RS02360 462308..462610 - 303 WP_075294105.1 DUF2442 domain-containing protein -
BTV17_RS02365 462579..462833 - 255 WP_075294104.1 DUF4160 domain-containing protein -
BTV17_RS02370 462965..463225 - 261 Protein_456 hemophilus-specific protein -
BTV17_RS02375 463302..463718 - 417 WP_075319814.1 IS200/IS605 family transposase -
BTV17_RS02380 463765..464901 + 1137 WP_075319813.1 transposase -
BTV17_RS02385 465157..466086 + 930 WP_075293400.1 hypothetical protein -
BTV17_RS02390 466105..466551 - 447 WP_075293401.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 463302..463718 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17344.33 Da        Isoelectric Point: 10.5585

>T70582 WP_075294106.1 NZ_CP018806:461162-461629 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALRNRQNRASRTFVICNENVVVGFYALAAGSVTHRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Download         Length: 468 bp

>T70582 NZ_CP018806:461162-461629 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAGAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCATCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCACCAATTGATGATATGTTATTGATGTTGAAGTTATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT70582 WP_011609927.1 NZ_CP018806:460897-461160 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT70582 NZ_CP018806:460897-461160 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References