Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 461685..462417 Replicon chromosome
Accession NZ_CP018804
Organism Histophilus somni strain USDA-ARS-USMARC-63368

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag BTV16_RS02355 Protein ID WP_075294106.1
Coordinates 461950..462417 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag BTV16_RS02350 Protein ID WP_011609927.1
Coordinates 461685..461948 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTV16_RS02320 456793..457155 + 363 WP_135026582.1 hypothetical protein -
BTV16_RS02325 457218..459506 + 2289 WP_075321885.1 hypothetical protein -
BTV16_RS10075 460172..460828 + 657 WP_157665518.1 hypothetical protein -
BTV16_RS02340 460982..461236 + 255 WP_075294108.1 DUF1778 domain-containing protein -
BTV16_RS02345 461236..461547 + 312 WP_075294107.1 hypothetical protein -
BTV16_RS02350 461685..461948 + 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
BTV16_RS02355 461950..462417 + 468 WP_075294106.1 GNAT family N-acetyltransferase Toxin
BTV16_RS02365 463096..463398 - 303 WP_075294105.1 DUF2442 domain-containing protein -
BTV16_RS02370 463367..463621 - 255 WP_075294104.1 DUF4160 domain-containing protein -
BTV16_RS02375 463753..464013 - 261 Protein_457 hemophilus-specific protein -
BTV16_RS02380 464090..464506 - 417 WP_075319814.1 IS200/IS605 family transposase -
BTV16_RS02385 464553..465689 + 1137 WP_075319813.1 transposase -
BTV16_RS02390 465945..466874 + 930 WP_075293400.1 hypothetical protein -
BTV16_RS02395 466893..467339 - 447 WP_075293401.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 464090..464506 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17344.33 Da        Isoelectric Point: 10.5585

>T70576 WP_075294106.1 NZ_CP018804:461950-462417 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALRNRQNRASRTFVICNENVVVGFYALAAGSVTHRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Download         Length: 468 bp

>T70576 NZ_CP018804:461950-462417 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAGAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCATCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCACCAATTGATGATATGTTATTGATGTTGAAGTTATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT70576 WP_011609927.1 NZ_CP018804:461685-461948 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT70576 NZ_CP018804:461685-461948 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References