Detailed information of TA system TA070575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1699611..1700092
• Replicon: chromosome
• Accession: NZ_CP018803
• Organism: Histophilus somni strain USDA-ARS-USMARC-63255

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BTV19_RS07820
• Protein ID: WP_075294307.1
• Coordinates: 1699832..1700092 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BTV19_RS07815
• Protein ID: WP_075294306.1
• Coordinates: 1699611..1699832 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTV19_RS07810	1697255..1699175	-	1921	Protein_1508	transferrin-binding protein-like solute binding protein	-
BTV19_RS07815	1699611..1699832	+	222	WP_075294306.1	CopG family transcriptional regulator	Antitoxin
BTV19_RS07820	1699832..1700092	+	261	WP_075294307.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTV19_RS07825	1700096..1700206	-	111	Protein_1511	CAAX protease	-
BTV19_RS07830	1700270..1701721	-	1452	WP_075294308.1	DUF560 domain-containing protein	-
BTV19_RS07835	1701837..1702028	-	192	WP_075294309.1	hypothetical protein	-
BTV19_RS07840	1702207..1702626	-	420	WP_075294310.1	pseudouridine synthase	-
BTV19_RS07845	1702692..1704032	-	1341	WP_075294311.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1690326..1728952	38626

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10029.68 Da
• Isoelectric Point: 9.9542

>T70575 WP_075294307.1 NZ_CP018803:1699832-1700092 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGTQKLILTWIANNLENCENPRIKGKGLTGNRSGEWRYRVGDYRIICDIRDSELIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T70575 NZ_CP018803:1699832-1700092 [Histophilus somni]
ATGTACACTTTACGGTATAGTGATAAGGCGTTGAAGCAACTATGCAAGCTTGATAAAGGCACACAAAAGTTGATTTTGAC
TTGGATAGCAAATAACTTAGAGAACTGCGAAAATCCAAGAATAAAAGGCAAAGGACTTACTGGGAATCGAAGTGGAGAAT
GGCGGTATAGAGTAGGCGACTATCGGATTATTTGTGATATACGAGATAGTGAATTGATAATACTTGCCTTGTCTATTGGA
CACAGGAAAAATATTTATTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8543.65 Da
• Isoelectric Point: 4.4284

>AT70575 WP_075294306.1 NZ_CP018803:1699611-1699832 [Histophilus somni]
MAISIRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEEYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT70575 NZ_CP018803:1699611-1699832 [Histophilus somni]
ATGGCTATTTCAATAAGATTAAACGCTCAAGACGAGCAATTATTTAAGTCCTATGCAAAAACAAATAATATTACGCTATC
CGAACTGTTCAGGAATGCCGTTTTTGAAAAAATCGAAGATGAATATGACCTTGCAGTATATCGTGAGTCTTTGGAAGAAT
ACAACAAAACCCCAATGAGTTATTCTCACGCAGAGGTATGCAAGATGTTAGGAATTGAGTGA