Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 460760..461492 Replicon chromosome
Accession NZ_CP018803
Organism Histophilus somni strain USDA-ARS-USMARC-63255

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag BTV19_RS02350 Protein ID WP_075294106.1
Coordinates 461025..461492 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag BTV19_RS02345 Protein ID WP_011609927.1
Coordinates 460760..461023 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTV19_RS02315 455868..456230 + 363 WP_135026582.1 hypothetical protein -
BTV19_RS02320 456293..458581 + 2289 WP_075321885.1 hypothetical protein -
BTV19_RS10060 459247..459903 + 657 WP_157665518.1 hypothetical protein -
BTV19_RS02335 460057..460311 + 255 WP_075294108.1 DUF1778 domain-containing protein -
BTV19_RS02340 460311..460622 + 312 WP_075294107.1 hypothetical protein -
BTV19_RS02345 460760..461023 + 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
BTV19_RS02350 461025..461492 + 468 WP_075294106.1 GNAT family N-acetyltransferase Toxin
BTV19_RS02360 462171..462473 - 303 WP_075294105.1 DUF2442 domain-containing protein -
BTV19_RS02365 462442..462696 - 255 WP_075294104.1 DUF4160 domain-containing protein -
BTV19_RS02370 462828..463088 - 261 Protein_456 hemophilus-specific protein -
BTV19_RS02375 463165..463581 - 417 WP_075319814.1 IS200/IS605 family transposase -
BTV19_RS02380 463628..464764 + 1137 WP_075319813.1 transposase -
BTV19_RS02385 465020..465949 + 930 WP_075293400.1 hypothetical protein -
BTV19_RS02390 465968..466414 - 447 WP_075293401.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 463165..463581 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17344.33 Da        Isoelectric Point: 10.5585

>T70573 WP_075294106.1 NZ_CP018803:461025-461492 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALRNRQNRASRTFVICNENVVVGFYALAAGSVTHRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Download         Length: 468 bp

>T70573 NZ_CP018803:461025-461492 [Histophilus somni]
ATGTATTCAGCACCTGAGCTATTAACACATCATCACCATTTAGGTGCATTTAATTGTGGTGAAGAGTCATTAAATATTTG
GCTTAAACGTCATGCACTTAGAAACCGGCAAAACCGAGCAAGTAGAACATTTGTGATCTGCAATGAAAATGTCGTTGTTG
GCTTCTATGCACTAGCGGCAGGTTCAGTGACGCATCGGTTTGTATCCGGAGCATTAAGACGTAATATGCCTGAGCCTATT
CCTGTTGTTGTTTTAGGAAGATTAGCTATAGATATAAAACATCAAGGAAAAAAATTAGGTGCTGCATTACTTAAAGATGT
TGTACTACGAGCAAGAGCTGTGTCAGAACAAGTTGGAGTAAGAGCTTTGCTCGTACACGCTTTAAATGATAAAGCAAAAC
AATTCTATCTCAATTATGGTTTTCAACCTTCACCAATTGATGATATGTTATTGATGTTGAAGTTATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT70573 WP_011609927.1 NZ_CP018803:460760-461023 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT70573 NZ_CP018803:460760-461023 [Histophilus somni]
ATGCGTACCGCTGCAATTAACCTACGAGTCCAGCCAAAGCAACGTGACTTAATTGATTATGCCGCTTCATTACTCGGAAA
AACACGTTCTGATTTTATGCTTGATGTTGCTTGCACTTATGCACAAAACGTGATTTTAGACAGAACAGTTTTTCAGCTTG
ATGAAGGAAAATTCAATCATTTTATTGAAGTACTTGAACAGCCTAATTTACCTAATGCCGGGTTGGAAAAATTAATGGCA
ACTCATTCACCTTGGGAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References