Detailed information of TA system TA070567

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4140639..4141453
• Replicon: chromosome
• Accession: NZ_CP018801
• Organism: Escherichia coli strain tolC-

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: BTD92_RS22200
• Protein ID: WP_001054376.1
• Coordinates: 4140639..4140896 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: BTD92_RS22205
• Protein ID: WP_001309181.1
• Coordinates: 4140908..4141453 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTD92_RS22175	4135927..4137033	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
BTD92_RS22180	4137098..4138078	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
BTD92_RS22190	4138661..4139901	-	1241	Protein_3959	helicase YjhR	-
BTD92_RS26495	4140017..4140262	+	246	Protein_3960	GNAT family N-acetyltransferase	-
BTD92_RS22200	4140639..4140896	+	258	WP_001054376.1	hypothetical protein	Toxin
BTD92_RS22205	4140908..4141453	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
BTD92_RS22210	4141509..4142255	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
BTD92_RS25965	4142424..4142642	+	219	Protein_3964	hypothetical protein	-
BTD92_RS26850	4142680..4142796	+	117	Protein_3965	VOC family protein	-
BTD92_RS22220	4143041..4144162	+	1122	WP_000010829.1	M42 family metallopeptidase	-
BTD92_RS22225	4144159..4144437	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
BTD92_RS22230	4144449..4145762	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4133133..4149677	16544

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T70567 WP_001054376.1 NZ_CP018801:4140639-4140896 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T70567 NZ_CP018801:4140639-4140896 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT70567 WP_001309181.1 NZ_CP018801:4140908-4141453 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT70567 NZ_CP018801:4140908-4141453 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8