Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1808317..1809148 Replicon chromosome
Accession NZ_CP018801
Organism Escherichia coli strain tolC-

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag BTD92_RS09355 Protein ID WP_000854814.1
Coordinates 1808317..1808691 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag BTD92_RS09360 Protein ID WP_001285584.1
Coordinates 1808780..1809148 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTD92_RS09315 1803713..1804879 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
BTD92_RS09320 1804998..1805471 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
BTD92_RS09325 1805669..1806727 + 1059 WP_001200891.1 FUSC family protein -
BTD92_RS09330 1806899..1807228 + 330 WP_000450409.1 DUF496 family protein -
BTD92_RS09335 1807329..1807511 - 183 WP_001016348.1 hypothetical protein -
BTD92_RS09340 1807583..1807711 + 129 Protein_1680 transposase domain-containing protein -
BTD92_RS26145 1808000..1808113 - 114 WP_001161660.1 DUF957 domain-containing protein -
BTD92_RS09350 1808126..1808320 - 195 WP_000988600.1 hypothetical protein -
BTD92_RS09355 1808317..1808691 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
BTD92_RS09360 1808780..1809148 - 369 WP_001285584.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
BTD92_RS09365 1809222..1809443 - 222 WP_000692323.1 DUF987 domain-containing protein -
BTD92_RS09370 1809506..1809952 - 447 WP_000187523.1 RadC family protein -
BTD92_RS09375 1809949..1811481 - 1533 WP_001350525.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T70544 WP_000854814.1 NZ_CP018801:c1808691-1808317 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T70544 NZ_CP018801:c1808691-1808317 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT70544 WP_001285584.1 NZ_CP018801:c1809148-1808780 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT70544 NZ_CP018801:c1809148-1808780 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References