Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1502214..1502830 Replicon chromosome
Accession NZ_CP018796
Organism Lentilactobacillus parabuchneri strain FAM21731

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FAM21731_RS06865 Protein ID WP_057910635.1
Coordinates 1502648..1502830 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FAM21731_RS06860 Protein ID WP_057910636.1
Coordinates 1502214..1502612 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAM21731_RS06840 1498038..1498952 + 915 WP_057910640.1 4-hydroxy-tetrahydrodipicolinate synthase -
FAM21731_RS06845 1499009..1499782 + 774 WP_057910639.1 4-hydroxy-tetrahydrodipicolinate reductase -
FAM21731_RS06850 1499804..1500991 + 1188 WP_057910638.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
FAM21731_RS06855 1501012..1502091 + 1080 WP_057910637.1 aspartate-semialdehyde dehydrogenase -
FAM21731_RS06860 1502214..1502612 - 399 WP_057910636.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FAM21731_RS06865 1502648..1502830 - 183 WP_057910635.1 type II toxin-antitoxin system HicA family toxin Toxin
FAM21731_RS06870 1503003..1503857 + 855 WP_057910634.1 metallophosphoesterase -
FAM21731_RS06875 1504287..1506686 + 2400 Protein_1311 phosphoketolase family protein -
FAM21731_RS06880 1506808..1507566 + 759 WP_075141188.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-113)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7053.28 Da        Isoelectric Point: 10.8513

>T70531 WP_057910635.1 NZ_CP018796:c1502830-1502648 [Lentilactobacillus parabuchneri]
MDSRTIIQMLKHDGWYKVRIHGDHWHFKHPQKLGIVTVPHPRKDIPKGTYNSILKQAGLK

Download         Length: 183 bp

>T70531 NZ_CP018796:c1502830-1502648 [Lentilactobacillus parabuchneri]
ATGGACTCCAGAACCATCATCCAGATGTTAAAACATGATGGGTGGTACAAAGTTAGAATCCATGGGGACCATTGGCATTT
TAAACACCCTCAAAAGCTGGGGATTGTAACTGTGCCACATCCTCGTAAAGATATTCCAAAAGGAACGTACAATAGCATTC
TAAAACAAGCGGGGCTCAAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14857.02 Da        Isoelectric Point: 6.2197

>AT70531 WP_057910636.1 NZ_CP018796:c1502612-1502214 [Lentilactobacillus parabuchneri]
MKYLYYALFKKQSDDKIEVTFPDLAPHAATYGTTMSDALHMAHDALEGYLLVVEDLHEKLPKASSPESLTHDTSQLIIPI
EVDTTLAREREDNVSIKKTLTIPKYLNDLGKQKSINFSATLTDALKHKLNIL

Download         Length: 399 bp

>AT70531 NZ_CP018796:c1502612-1502214 [Lentilactobacillus parabuchneri]
ATGAAATATTTGTATTATGCTTTATTCAAAAAGCAATCAGATGACAAAATTGAAGTTACATTCCCTGACTTAGCCCCCCA
CGCAGCAACATATGGAACAACGATGTCAGATGCCCTTCATATGGCTCATGATGCCTTGGAAGGCTACTTATTAGTTGTTG
AGGATTTACACGAGAAGCTGCCTAAGGCTTCAAGTCCAGAATCATTAACACATGATACAAGCCAGCTGATCATTCCTATC
GAGGTCGACACAACGTTGGCACGGGAACGTGAAGACAATGTAAGTATCAAAAAGACGTTAACAATTCCAAAATATTTAAA
TGATTTAGGCAAGCAAAAAAGCATCAATTTCTCTGCCACACTCACGGATGCCTTAAAGCACAAGCTCAATATTTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References