70528

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1867983..1869460 Replicon chromosome
Accession NZ_CP018787
Organism Oxalobacter formigenes strain HC-1

Toxin (Protein)


Gene name HipA1 Uniprot ID C3X8C7
Locus tag BRW83_RS09005 Protein ID WP_005879940.1
Coordinates 1867983..1869239 (-) Length 419 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag BRW83_RS09010 Protein ID WP_005879938.1
Coordinates 1869236..1869460 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BRW83_RS08990 1864748..1865233 - 486 WP_036602666.1 hypothetical protein -
BRW83_RS08995 1866176..1867042 + 867 WP_005879944.1 hypothetical protein -
BRW83_RS09000 1867099..1867974 + 876 WP_005879942.1 hypothetical protein -
BRW83_RS09005 1867983..1869239 - 1257 WP_005879940.1 type II toxin-antitoxin system HipA family toxin Toxin
BRW83_RS09010 1869236..1869460 - 225 WP_005879938.1 helix-turn-helix transcriptional regulator Antitoxin
BRW83_RS09015 1869649..1870026 - 378 WP_036602664.1 DUF1622 domain-containing protein -
BRW83_RS09020 1870289..1870936 + 648 WP_036603576.1 NAD(P)H-binding protein -
BRW83_RS09025 1870948..1871403 + 456 WP_036602661.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-351)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-66)


Sequences

Toxin        


Download         Length: 419 a.a.        Molecular weight: 46365.63 Da        Isoelectric Point: 6.7525

>T70528 WP_005879940.1 NZ_CP018787:c1869239-1867983 [Oxalobacter formigenes]
MSRILDVYLHEKMAGTLAQNENGQLVFKYNSNYLDSNGMAISVSMPLRDEPYPDRIARPYFAGLLPDERARRRLAAVLGV
SDENVFGLLEIIGGECAGALSLLPQGQPLPDFSTGTVEVLDGKRLAELLDLLRQKPLLGGVEGIRLSLAGAQDKLAVCFI
DGQIFLPKNGLPTTHILKPFIEGLSGTVENEVFCMMLAGRVGLDAPVVSKGMAGNTGFILVERYDRVREENGRILRLHQE
DFCQALGVPPEIKYESEGGPGIASSQALIQNVTQRPAADRRAFQQRVIFHYLVGNADAHAKNYSLLYQGKTPVLAPVYDV
VCTDVYSLAKNMAMKIGERSLPDTIRLEDWQKMVPDTRVAKRILSDDLLRMANGIEIEADRLLEELNDQNLYHPVLKKIR
RTIGVRVRTIQKLMEKIA

Download         Length: 1257 bp

>T70528 NZ_CP018787:c1869239-1867983 [Oxalobacter formigenes]
ATGAGTCGCATTCTTGATGTTTACCTTCATGAAAAGATGGCGGGTACGCTGGCGCAAAATGAGAATGGCCAACTTGTTTT
CAAATATAACAGTAATTATCTGGATTCAAACGGGATGGCAATTTCAGTATCGATGCCTTTACGTGATGAGCCTTACCCGG
ACAGGATCGCTCGTCCGTACTTTGCCGGTTTGTTGCCGGACGAACGTGCGCGACGTCGTCTTGCGGCTGTGTTGGGTGTT
TCTGATGAAAATGTTTTCGGTTTGCTGGAGATAATCGGTGGTGAATGTGCAGGTGCACTTTCCCTGTTACCGCAAGGACA
ACCGTTGCCCGATTTTTCTACCGGAACTGTCGAGGTACTCGACGGGAAACGTCTTGCTGAACTGCTGGACCTGTTACGGC
AAAAACCATTGCTTGGAGGTGTGGAAGGAATTCGCTTATCTCTTGCCGGGGCACAGGATAAACTGGCCGTTTGTTTCATT
GACGGGCAAATTTTTTTGCCCAAAAACGGACTTCCGACCACACATATTCTCAAACCTTTTATCGAAGGATTGAGCGGAAC
GGTTGAAAACGAGGTTTTCTGTATGATGCTGGCGGGGCGCGTGGGATTGGATGCGCCTGTCGTTTCCAAAGGCATGGCAG
GAAATACCGGATTCATTCTTGTTGAACGTTATGACCGTGTGCGCGAAGAGAATGGCAGGATTTTACGCTTGCATCAGGAA
GATTTCTGTCAGGCTCTGGGTGTGCCGCCGGAAATTAAATATGAATCGGAAGGTGGGCCGGGAATAGCCAGTTCACAGGC
GTTGATCCAGAATGTAACGCAGAGGCCGGCTGCCGATCGTCGTGCTTTTCAGCAAAGGGTGATTTTTCATTATCTGGTGG
GAAACGCGGATGCTCATGCCAAAAATTATTCCCTGCTATATCAGGGCAAGACGCCCGTTCTGGCTCCGGTTTACGATGTC
GTATGTACAGATGTATATTCTCTTGCAAAGAATATGGCCATGAAAATTGGTGAGCGCTCTCTGCCAGATACCATACGATT
GGAAGACTGGCAAAAAATGGTACCGGACACCCGGGTGGCAAAAAGGATATTGTCTGATGATTTATTACGAATGGCGAATG
GTATAGAAATCGAAGCGGACAGGCTTCTGGAAGAATTGAACGACCAAAATCTTTATCATCCGGTGTTGAAAAAAATCAGG
AGAACGATCGGTGTCCGGGTGCGAACGATTCAAAAGCTTATGGAAAAAATTGCCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8124.44 Da        Isoelectric Point: 10.5957

>AT70528 WP_005879938.1 NZ_CP018787:c1869460-1869236 [Oxalobacter formigenes]
MTSVQNHIALGNLVRIERKRQKLTQEQLAALAGVGVRFLRELEKGKDSCRIGLAFSVMQTLGLSVDVSGRGDEK

Download         Length: 225 bp

>AT70528 NZ_CP018787:c1869460-1869236 [Oxalobacter formigenes]
ATGACTTCAGTTCAAAATCATATTGCACTTGGCAATCTTGTTCGTATCGAACGGAAGCGTCAGAAGTTGACACAGGAGCA
ACTGGCTGCGCTTGCCGGTGTGGGTGTCCGGTTTTTACGTGAGCTGGAAAAAGGAAAGGACAGTTGTCGAATCGGTCTTG
CGTTTTCTGTCATGCAAACCCTTGGGTTGTCTGTGGATGTTTCCGGAAGAGGAGACGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C3X8C7

Antitoxin

Source ID Structure

References