Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3860064..3860721 Replicon chromosome
Accession NZ_CP018785
Organism Enterobacter ludwigii strain AA4

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag BUE86_RS18680 Protein ID WP_014171514.1
Coordinates 3860311..3860721 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag BUE86_RS18675 Protein ID WP_003863437.1
Coordinates 3860064..3860330 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUE86_RS18655 3855471..3856904 - 1434 WP_020883728.1 6-phospho-beta-glucosidase BglA -
BUE86_RS18660 3857021..3857752 - 732 WP_020883729.1 MurR/RpiR family transcriptional regulator -
BUE86_RS18665 3858019..3858678 + 660 WP_014171517.1 hemolysin III family protein -
BUE86_RS18670 3858789..3859769 - 981 WP_079231695.1 tRNA-modifying protein YgfZ -
BUE86_RS18675 3860064..3860330 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
BUE86_RS18680 3860311..3860721 + 411 WP_014171514.1 protein YgfX Toxin
BUE86_RS18685 3860728..3861249 - 522 WP_014171513.1 flavodoxin FldB -
BUE86_RS18690 3861351..3862247 + 897 WP_014171511.1 site-specific tyrosine recombinase XerD -
BUE86_RS18695 3862271..3862984 + 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BUE86_RS18700 3862990..3864723 + 1734 WP_044866092.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T70525 WP_014171514.1 NZ_CP018785:3860311-3860721 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T70525 NZ_CP018785:3860311-3860721 [Enterobacter ludwigii]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGAGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT70525 WP_003863437.1 NZ_CP018785:3860064-3860330 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT70525 NZ_CP018785:3860064-3860330 [Enterobacter ludwigii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References