Detailed information of TA system TA070524

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2505710..2506226
• Replicon: chromosome
• Accession: NZ_CP018785
• Organism: Enterobacter ludwigii strain AA4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BUE86_RS11985
• Protein ID: WP_079231471.1
• Coordinates: 2505710..2505994 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BUE86_RS11990
• Protein ID: WP_079231472.1
• Coordinates: 2505984..2506226 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BUE86_RS11965	2502025..2502597	+	573	WP_079231468.1	PTS sugar transporter subunit IIA	-
BUE86_RS11975	2502965..2505103	+	2139	WP_079231470.1	anaerobic ribonucleoside-triphosphate reductase	-
BUE86_RS11980	2505242..2505706	+	465	WP_059306428.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
BUE86_RS11985	2505710..2505994	-	285	WP_079231471.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BUE86_RS11990	2505984..2506226	-	243	WP_079231472.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BUE86_RS11995	2506304..2508214	-	1911	WP_014168384.1	BglG family transcription antiterminator	-
BUE86_RS12000	2508234..2509370	-	1137	WP_079231473.1	lactonase family protein	-
BUE86_RS12005	2509489..2510229	-	741	WP_047355607.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10936.75 Da
• Isoelectric Point: 10.3202

>T70524 WP_079231471.1 NZ_CP018785:c2505994-2505710 [Enterobacter ludwigii]
MSYELVFDPRAFKEWTRLGDTVKNQFKKKLANVLVNPWVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVCVITIGK
REKSAVSHDVNKRL

Nucleotide

• Length: 285 bp

>T70524 NZ_CP018785:c2505994-2505710 [Enterobacter ludwigii]
ATGAGTTATGAACTCGTATTTGATCCGAGGGCGTTCAAGGAGTGGACCAGGCTGGGTGATACCGTAAAAAATCAGTTTAA
GAAGAAGCTTGCGAACGTGTTGGTGAACCCCTGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCTACAAGATAA
AACTCAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTGACGGTATGTGTTATTACTATCGGTAAG
AGAGAGAAATCAGCCGTTTCTCATGACGTAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9100.50 Da
• Isoelectric Point: 4.8146

>AT70524 WP_079231472.1 NZ_CP018785:c2506226-2505984 [Enterobacter ludwigii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDELIQTVRERLADPQKGIKVRLDEL

Nucleotide

• Length: 243 bp

>AT70524 NZ_CP018785:c2506226-2505984 [Enterobacter ludwigii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTTGAAAAACTCAATATCACGCC
AACGGAAGCCGTTCGGTTACTGTTTCAGTACGTTGCGGAGACGGGGCGTATGCCGGTGAAAACGGTCACTGTTAGCGACA
GTGAAGATGAACTCATACAGACAGTCCGGGAGCGGCTGGCTGATCCGCAAAAAGGAATTAAGGTTAGGCTGGATGAGTTA
TGA