Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 135751..136338 Replicon plasmid pOAAA2
Accession NZ_CP018781
Organism Brucella pituitosa strain AA2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BUE85_RS16825 Protein ID WP_079212732.1
Coordinates 135751..135939 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BUE85_RS16830 Protein ID WP_079212733.1
Coordinates 135943..136338 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUE85_RS16790 130774..131490 - 717 WP_152027365.1 hypothetical protein -
BUE85_RS16795 131549..132312 - 764 Protein_120 IS5 family transposase -
BUE85_RS16800 132354..132689 - 336 WP_079212727.1 hypothetical protein -
BUE85_RS25835 132689..132871 - 183 WP_152027366.1 hypothetical protein -
BUE85_RS16805 132871..133827 - 957 WP_079212728.1 phage tail protein -
BUE85_RS16810 133824..134621 - 798 WP_079212729.1 glucosaminidase domain-containing protein -
BUE85_RS26125 134756..135097 - 342 WP_161492445.1 hypothetical protein -
BUE85_RS16820 135100..135660 - 561 WP_152027367.1 macro domain-containing protein -
BUE85_RS16825 135751..135939 + 189 WP_079212732.1 type II toxin-antitoxin system HicA family toxin Toxin
BUE85_RS16830 135943..136338 + 396 WP_079212733.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BUE85_RS16835 136456..137436 + 981 WP_079212877.1 IS5 family transposase -
BUE85_RS16845 137676..137924 - 249 WP_079212735.1 hypothetical protein -
BUE85_RS16850 138129..138602 - 474 WP_079212736.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..332144 332144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6922.22 Da        Isoelectric Point: 11.1422

>T70513 WP_079212732.1 NZ_CP018781:135751-135939 [Brucella pituitosa]
MKSGDILKILENDGWKMVAQKGSHIQLKHPTKPGRVTVPHPKRDVPIGTLKSIEKQSGLKLR

Download         Length: 189 bp

>T70513 NZ_CP018781:135751-135939 [Brucella pituitosa]
ATGAAGAGCGGTGATATTTTAAAGATTTTAGAAAATGATGGCTGGAAGATGGTCGCTCAAAAGGGAAGCCATATCCAGCT
AAAGCATCCTACTAAGCCGGGGCGCGTGACCGTTCCGCATCCTAAAAGAGACGTTCCTATTGGAACACTCAAGAGTATCG
AAAAACAATCTGGACTGAAATTGAGGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14273.96 Da        Isoelectric Point: 4.1237

>AT70513 WP_079212733.1 NZ_CP018781:135943-136338 [Brucella pituitosa]
MRNYIGLIHKDADSDYGVSFPDFPGVITAGRDLDEARQMAEEALAFHIEGLVEDGEAIPEPSSLEAVMTDPDNKDGVAIL
VALKSETKKAVRINITMQEDILQEIDAYAEENGLTRSGFLARAAKHELEAA

Download         Length: 396 bp

>AT70513 NZ_CP018781:135943-136338 [Brucella pituitosa]
ATGCGAAACTATATCGGACTGATCCACAAGGACGCCGACAGCGATTATGGCGTCTCTTTTCCAGATTTTCCCGGCGTTAT
TACAGCCGGGCGCGATCTGGATGAAGCACGTCAAATGGCAGAAGAAGCACTTGCTTTTCATATTGAAGGGTTGGTTGAAG
ATGGCGAGGCCATTCCTGAACCTTCCAGCTTAGAGGCAGTAATGACGGACCCGGACAATAAGGATGGCGTTGCAATTCTT
GTTGCCCTGAAAAGCGAAACTAAAAAGGCCGTTCGCATCAACATCACCATGCAAGAGGATATTTTGCAGGAGATTGACGC
CTACGCAGAAGAAAATGGCCTTACTCGTTCAGGCTTTCTTGCCAGAGCCGCAAAACACGAACTTGAAGCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References