Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RHH
Location 569243..569799 Replicon chromosome
Accession NZ_CP018779
Organism Brucella pituitosa strain AA2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BUE85_RS02515 Protein ID WP_079210887.1
Coordinates 569506..569799 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BUE85_RS02510 Protein ID WP_079210886.1
Coordinates 569243..569518 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUE85_RS02485 565634..565954 + 321 Protein_478 Tn3 family transposase -
BUE85_RS02490 566003..566401 - 399 WP_079210884.1 type II toxin-antitoxin system VapC family toxin -
BUE85_RS02495 566398..566649 - 252 WP_079211290.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
BUE85_RS26170 567413..567595 + 183 Protein_481 integrase core domain-containing protein -
BUE85_RS02505 568039..569040 + 1002 WP_079210885.1 IS30 family transposase -
BUE85_RS02510 569243..569518 + 276 WP_079210886.1 CopG family ribbon-helix-helix protein Antitoxin
BUE85_RS02515 569506..569799 + 294 WP_079210887.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BUE85_RS02520 570003..570119 + 117 Protein_485 transposase -
BUE85_RS02525 570324..570710 + 387 WP_161492396.1 serine protease -
BUE85_RS02530 570894..571778 + 885 WP_079210889.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD -
BUE85_RS02535 571824..572042 - 219 Protein_488 helix-turn-helix domain-containing protein -
BUE85_RS02540 572076..573068 + 993 WP_079211291.1 IS5 family transposase -
BUE85_RS02545 573119..574256 - 1138 Protein_490 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 571890..573068 1178


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-41)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10989.68 Da        Isoelectric Point: 10.2754

>T70511 WP_079210887.1 NZ_CP018779:569506-569799 [Brucella pituitosa]
VPHLIWTPQAAASVQRLHRFLVTKDADAARRAVKAIRAGMKILAHQPHIGRPIDDMGPEFREWLIDFGDSGYVALYRVSH
DHISILAVRHQKEAGYK

Download         Length: 294 bp

>T70511 NZ_CP018779:569506-569799 [Brucella pituitosa]
GTGCCACACCTAATTTGGACGCCGCAGGCGGCGGCCAGCGTGCAGCGCCTGCATCGCTTCTTAGTGACCAAGGATGCCGA
CGCAGCGCGGCGGGCGGTGAAGGCCATCAGGGCAGGGATGAAGATTCTGGCGCATCAGCCGCATATCGGGCGCCCGATCG
ACGATATGGGGCCAGAATTCCGGGAATGGCTTATTGACTTCGGAGATAGCGGATATGTGGCTCTATATCGCGTCTCACAC
GATCATATCAGCATCTTGGCTGTACGGCATCAAAAAGAAGCAGGCTACAAATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10613.92 Da        Isoelectric Point: 4.6896

>AT70511 WP_079210886.1 NZ_CP018779:569243-569518 [Brucella pituitosa]
MAVTSVKLDDELKGRVQLLAASRRRTPHWIMREAIAEYVEREEKRESFKREALEAWEDYQRTGLHLTGEEVDEWLAKLEA
GEDAEMPACHT

Download         Length: 276 bp

>AT70511 NZ_CP018779:569243-569518 [Brucella pituitosa]
ATGGCAGTTACATCGGTCAAGCTCGATGACGAGCTGAAGGGCCGCGTCCAGCTTCTGGCCGCGTCTCGCCGCCGCACACC
GCACTGGATAATGCGCGAGGCCATCGCGGAATACGTCGAGCGCGAAGAAAAGCGAGAATCTTTCAAGCGTGAAGCCTTAG
AGGCATGGGAAGACTACCAACGCACTGGCCTGCATCTCACCGGCGAAGAAGTTGACGAATGGCTTGCTAAGCTGGAAGCC
GGTGAAGATGCGGAGATGCCCGCGTGCCACACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References