Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 74376..74950 Replicon chromosome
Accession NZ_CP018779
Organism Brucella pituitosa strain AA2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BUE85_RS00315 Protein ID WP_079210523.1
Coordinates 74376..74753 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BUE85_RS00320 Protein ID WP_079210524.1
Coordinates 74750..74950 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUE85_RS00300 70230..71135 + 906 WP_079210521.1 3-keto-5-aminohexanoate cleavage protein -
BUE85_RS00305 71141..72619 + 1479 WP_079210522.1 carnitine 3-dehydrogenase -
BUE85_RS00310 72907..74028 - 1122 WP_079211252.1 Fic family protein -
BUE85_RS00315 74376..74753 - 378 WP_079210523.1 type II toxin-antitoxin system VapC family toxin Toxin
BUE85_RS00320 74750..74950 - 201 WP_079210524.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BUE85_RS00325 75190..76731 - 1542 WP_079210525.1 Fic family protein -
BUE85_RS25550 77004..77102 + 99 Protein_65 IS6 family transposase -
BUE85_RS00330 77528..77782 + 255 WP_079210526.1 type II toxin-antitoxin system ParD family antitoxin -
BUE85_RS00335 77782..78075 + 294 WP_079210527.1 type II toxin-antitoxin system RelE/ParE family toxin -
BUE85_RS00340 78662..78922 + 261 WP_079210528.1 type II toxin-antitoxin system ParD family antitoxin -
BUE85_RS00345 78925..79214 + 290 Protein_69 type II toxin-antitoxin system RelE/ParE family toxin -
BUE85_RS00350 79351..79620 + 270 WP_152027218.1 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 77528..86766 9238
- inside Prophage - - 60307..76731 16424
- flank IS/Tn - - 77004..77126 122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14045.29 Da        Isoelectric Point: 5.9730

>T70507 WP_079210523.1 NZ_CP018779:c74753-74376 [Brucella pituitosa]
VILADTSIWIDHFRSGDNELIKIIADDLLLCHPAIIGELALGSLRDRTSVLAFLNVQREAQVATHDEVMTMIEMHCIFSM
GIGYTDAQLLASVLLDRRTSLWTRDKRLKITAEKAGARLYEPLHS

Download         Length: 378 bp

>T70507 NZ_CP018779:c74753-74376 [Brucella pituitosa]
GTGATTTTGGCAGACACTTCAATTTGGATTGACCATTTCCGCAGCGGCGATAATGAGCTCATTAAAATTATCGCTGATGA
TCTTTTGCTTTGCCATCCAGCGATTATAGGCGAACTTGCGTTGGGGAGTCTCCGAGACAGGACGAGTGTATTGGCTTTTT
TGAATGTACAGCGTGAAGCTCAAGTCGCAACACATGACGAAGTCATGACCATGATTGAAATGCACTGCATTTTTAGCATG
GGCATTGGCTATACTGATGCCCAATTGCTGGCATCAGTTCTTCTCGACCGGCGAACTTCACTGTGGACCCGAGACAAGCG
CTTAAAGATTACGGCTGAAAAAGCCGGTGCACGGCTTTACGAGCCGCTGCACAGTTAA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7304.50 Da        Isoelectric Point: 10.9054

>AT70507 WP_079210524.1 NZ_CP018779:c74950-74750 [Brucella pituitosa]
MRSTINLDDNLLEKARLLTGTKETAALVRQALETLVRLETGKRLIALGGTMPDVEAAPRRRSSEKK

Download         Length: 201 bp

>AT70507 NZ_CP018779:c74950-74750 [Brucella pituitosa]
ATGCGCTCAACCATCAATCTTGATGACAATCTTTTAGAAAAAGCCAGATTGTTGACCGGAACGAAAGAGACAGCCGCTTT
AGTCCGACAAGCGCTAGAAACACTTGTGCGACTAGAGACTGGTAAACGCCTTATCGCTCTTGGAGGCACGATGCCGGACG
TTGAAGCAGCTCCTCGCCGTCGGAGCTCAGAGAAGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References