Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3707628..3708302 Replicon chromosome
Accession NZ_CP018778
Organism Mycobacterium tuberculosis strain DK9897

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag BTU11_RS18235 Protein ID WP_003417282.1
Coordinates 3707628..3708056 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag BTU11_RS18240 Protein ID WP_003417286.1
Coordinates 3708060..3708302 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTU11_RS18210 3703450..3703851 - 402 WP_003417264.1 cytidine deaminase -
BTU11_RS18215 3703992..3704426 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
BTU11_RS18220 3704423..3704857 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
BTU11_RS18225 3704986..3706758 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
BTU11_RS18230 3706758..3707549 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
BTU11_RS18235 3707628..3708056 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
BTU11_RS18240 3708060..3708302 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
BTU11_RS18245 3708424..3709038 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
BTU11_RS18250 3709035..3709700 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
BTU11_RS18255 3709701..3710234 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
BTU11_RS18260 3710231..3710320 - 90 WP_009934953.1 pterin-4-alpha-carbinolamine dehydratase moaB3 -
BTU11_RS18270 3710419..3711680 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T70502 WP_003417282.1 NZ_CP018778:c3708056-3707628 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T70502 NZ_CP018778:c3708056-3707628 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT70502 WP_003417286.1 NZ_CP018778:c3708302-3708060 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT70502 NZ_CP018778:c3708302-3708060 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References