Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3110212..3110740 Replicon chromosome
Accession NZ_CP018778
Organism Mycobacterium tuberculosis strain DK9897

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag BTU11_RS15365 Protein ID WP_044108447.1
Coordinates 3110212..3110526 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag BTU11_RS15370 Protein ID WP_003901465.1
Coordinates 3110510..3110740 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTU11_RS15345 3105622..3107310 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
BTU11_RS15350 3107314..3107640 - 327 WP_003414157.1 hypothetical protein -
BTU11_RS15355 3107813..3108400 + 588 WP_003914429.1 DUF3558 family protein -
BTU11_RS15360 3108419..3110068 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
BTU11_RS15365 3110212..3110526 - 315 WP_044108447.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BTU11_RS15370 3110510..3110740 - 231 WP_003901465.1 antitoxin MazE Antitoxin
BTU11_RS15375 3110783..3111826 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
BTU11_RS21865 3112017..3112292 + 276 WP_003911993.1 DUF1778 domain-containing protein -
BTU11_RS21870 3112468..3112722 - 255 WP_003917684.1 hypothetical protein -
BTU11_RS15395 3112870..3113274 + 405 WP_009938577.1 hypothetical protein -
BTU11_RS15400 3113271..3113462 + 192 WP_003414184.1 hypothetical protein -
BTU11_RS15405 3113526..3114815 + 1290 Protein_2902 transposase family protein -
BTU11_RS15410 3115049..3115306 + 258 WP_003899489.1 hypothetical protein -
BTU11_RS15415 3115411..3115722 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11195.82 Da        Isoelectric Point: 10.7779

>T70497 WP_044108447.1 NZ_CP018778:c3110526-3110212 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELA

Download         Length: 315 bp

>T70497 NZ_CP018778:c3110526-3110212 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT70497 WP_003901465.1 NZ_CP018778:c3110740-3110510 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT70497 NZ_CP018778:c3110740-3110510 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References